Timing of eating in adults across the weight spectrum: Metabolic factors and potential circadian mechanisms.

Timing of eating in adults across the weight spectrum: Metabolic factors and potential circadian mechanisms.
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DOI:
10.1016/j.physbeh.2018.02.047
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发表时间:
2018-08-01
影响因子:
2.9
通讯作者:
Goel N
Goel N
中科院分区:
医学3区
文献类型:
--
作者:
Allison KC;Goel N

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进食时间被认为是体重调节的重要因素。睡眠-觉醒周期从主要的白天(白天)到延迟(晚上)的生活方式的中断会导致昼夜节律的改变和代谢功能障碍。这篇文章回顾了目前在正常体重和超重或肥胖者中定时和延迟进食的证据:一些发现表明在白天早些时候进食对体重和/或代谢结果有好处,尽管这些发现并不是一致的,还需要更严格和更长时间的研究。我们还回顾了饮食时间变化对新陈代谢和体重相关的影响所产生的潜在的昼夜节律机制。需要使用深层表型进一步确定机制,以确定肥胖症、代谢综合征和糖尿病预防的医疗干预目标,并为控制体重和代谢性疾病的饮食时间表提供临床指南。
Timing of eating is recognized as a significant contributor to body weight regulation. Disruption of sleep-wake cycles from a predominantly diurnal (daytime) to a delayed (evening) lifestyle leads to altered circadian rhythms and metabolic dysfunction. This article reviews current evidence for timed and delayed eating in individuals of normal weight and those with overweight or obesity: some findings indicate a benefit of eating earlier in the daytime on weight and/or metabolic outcomes, although the findings have not been uniformly consistent, and more rigorous and longer-duration studies are needed. We also review potential circadian mechanisms resulting from the metabolic- and weight-related impact of changes in timing of eating. Further identification of mechanisms using deep phenotyping is required to determine targets for medical interventions for obesity and for prevention of metabolic syndrome and diabetes, and to inform clinical guidelines regarding eating schedules for management of weight and metabolic disease.
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