Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States.
Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States.
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DOI：
10.1371/journal.pone.0016103
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发表时间：
2011-02-17
期刊：
影响因子：
3.7
通讯作者：
Aiello AE
中科院分区：
文献类型：
--
作者：
Simanek AM;Dowd JB;Pawelec G;Melzer D;Dutta A;Aiello AE
研究表明，CMV感染可能会影响心血管疾病（CVD）的风险和死亡率。然而，一直没有大规模的检查，这些人口之间的关系不同的人口。炎症标志物C-反应蛋白（CRP）也与CVD结局和死亡率相关，并可能在CMV和死亡率之间的通路中发挥重要作用。我们利用一项美国全国代表性研究来检查CMV感染是否与全因死亡率和CVD相关死亡率相关。我们还评估了CRP水平是否介导或修改这些关系。数据来自2006年12月31日在国家健康与营养调查（NHANES）III（1988-1994）中接受CMV和CRP水平检测并有资格接受死亡率随访的≥25岁受试者（N = 14153）。 使用考克斯比例风险模型估计CMV血清状态下全因和CVD相关死亡率的风险比（HR）和95%置信区间（CI）。调整多种混杂因素后，CMV血清阳性与全因死亡率仍具有统计学显著相关性（HR 1.19，95% CI：1.01，1.41）。调整混杂因素后，CMV和CVD相关死亡率之间的相关性未达到统计学显著性。CRP没有调解这些协会。然而，与CRP水平低的CMV血清阳性个体相比，CRP水平高的CMV血清阳性个体的全因死亡风险高30.1%，CVD相关死亡风险高29.5%。CMV与全因死亡风险显著增加相关，同时CRP水平较高的CMV血清阳性受试者的全因死亡和CVD相关死亡风险均显著高于CRP水平较低的受试者。未来的工作应该针对CMV感染和低水平炎症相互作用对死亡率产生重大影响的机制。
Studies have suggested that CMV infection may influence cardiovascular disease (CVD) risk and mortality. However, there have been no large-scale examinations of these relationships among demographically diverse populations. The inflammatory marker C-reactive protein (CRP) is also linked with CVD outcomes and mortality and may play an important role in the pathway between CMV and mortality. We utilized a U.S. nationally representative study to examine whether CMV infection is associated with all-cause and CVD-related mortality. We also assessed whether CRP level mediated or modified these relationships. Data come from subjects ≥25 years of age who were tested for CMV and CRP level and were eligible for mortality follow-up on December 31st, 2006 (N = 14153) in the National Health and Nutrition Examination Survey (NHANES) III (1988–1994). Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause and CVD-related mortality by CMV serostatus. After adjusting for multiple confounders, CMV seropositivity remained statistically significantly associated with all-cause mortality (HR 1.19, 95% CI: 1.01, 1.41). The association between CMV and CVD-related mortality did not achieve statistical significance after confounder adjustment. CRP did not mediate these associations. However, CMV seropositive individuals with high CRP levels showed a 30.1% higher risk for all-cause mortality and 29.5% higher risk for CVD-related mortality compared to CMV seropositive individuals with low CRP levels. CMV was associated with a significant increased risk for all-cause mortality and CMV seropositive subjects who also had high CRP levels were at substantially higher risk for both for all-cause and CVD-related mortality than subjects with low CRP levels. Future work should target the mechanisms by which CMV infection and low-level inflammation interact to yield significant impact on mortality.
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DOI：
10.1126/science.1185350
发表时间：
2010-04-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hansen SG;Powers CJ;Richards R;Ventura AB;Ford JC;Siess D;Axthelm MK;Nelson JA;Jarvis MA;Picker LJ;Früh K
通讯作者：
Früh K
影响因子：
168.9
作者：
Bason, C;Corrocher, R;Puccetti, A
通讯作者：
Puccetti, A
影响因子：
4.4
作者：
Hadrup, SR;Strindhall, J;Wikby, A
通讯作者：
Wikby, A
影响因子：
4.2
作者：
Dowd, J. B.;Aiello, A. E.;Alley, D. E.
通讯作者：
Alley, D. E.
DOI：
10.1093/gerona/63.6.610
发表时间：
2008-06-01
影响因子：
5.1
作者：
Aiello, Allison E.;Haan, Mary N.;Liang, Jersey
通讯作者：
Liang, Jersey