Comparison and consensus guidelines for delineation of clinical target volume for CT- and MR-based brachytherapy in locally advanced cervical cancer.
Comparison and consensus guidelines for delineation of clinical target volume for CT- and MR-based brachytherapy in locally advanced cervical cancer.
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DOI：
10.1016/j.ijrobp.2014.06.005
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发表时间：
2014-10-01
影响因子：
7
通讯作者：
Bosch, Walter
中科院分区：
文献类型：
--
作者：
Viswanathan, Akila N.;Erickson, Beth;Gaffney, David K.;Beriwal, Sushil;Bhatia, Sudershan K.;Burnett, Omer Lee, III;D'Souza, David P.;Patil, Nikhilesh;Haddock, Michael G.;Jhingran, Anuja;Jones, Ellen L.;Kunos, Charles A.;Lee, Larissa J.;Lin, Lilie L.;Mayr, Nina A.;Petersen, Ivy;Petric, Primoz;Portelance, Lorraine;Small, William, Jr.;Strauss, Jonathan B.;Townamchai, Kanokpis;Wolfson, Aaron H.;Yashar, Catheryn M.;Bosch, Walter
为了创建和比较基于计算机断层扫描（CT）和3个Tesla （3T）磁共振（MR）图像的宫颈癌近距离放射治疗的共识临床靶体积（CTV）轮廓：23名妇科放射肿瘤学专家绘制了相同的3例宫颈癌近距离放射治疗病例：1例IIB期接近完全缓解（CR）病例采用串联和卵形，1例IIB期部分缓解（PR）病例采用卵形针，1例IB2期CR病例采用环形涂抹器。CT等高线在MRI等高线之前完成。使用同时真实性和性能水平估计（STAPLE）的期望最大化算法分析这些目标描述的一致性和清晰度，并使用kappa统计作为参与者之间协议的度量。计算六个数据集的一致性指数（CI）。生成骰子系数以比较同一病例的CT和MR轮廓。3例患者MR上的平均肿瘤体积均小于CT （p<0.001）。CT的Kappa和CI估计值略高，表明CT的一致性更高。合并CR的IB2期患者的DICE系数为89%，合并PR的IIB期患者的DICE系数为74%，合并CR的IIB期患者的DICE系数为57%。当比较MR-与CT等高线CTV体积时，CT上的一致性更高可能是由于近距离治疗时图像上的对比度更明显。在近距离治疗时，最大的差异是在诊断时进行参数扩展的病例中，由于CT上出现了参数，而mr上没有，诊断时几乎完全缓解。基于这些结果，CT和mr的一致性为95%，在线轮廓图集可在http://www.nrgoncology.org/Resources/ContouringAtlases.aspx上获得指导。
To create and compare consensus clinical target volume (CTV) contours for computed tomography (CT) and 3 Tesla (3T) magnetic resonance (MR) image-based cervical-cancer brachytherapy Twenty-three gynecologic radiation oncology experts contoured the same 3 cervical-cancer brachytherapy cases: one Stage IIB near-complete response (CR) case with a tandem and ovoid, one Stage IIB partial response (PR) case with ovoid with needles and one Stage IB2 CR case with a ring applicator. CT contours were completed before MRI contours. These were analyzed for consistency and clarity of target delineation using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE), with kappa statistics as a measure of agreement between participants. The conformity index (CI) was calculated for each of the six data sets. Dice coefficients were generated to compare CT and MR contours of the same case. For all 3 cases, the mean tumor volume was smaller on MR than on CT (p<0.001). Kappa and CI estimates were slightly higher for CT, indicating a higher level of agreement on CT. DICE coefficients were 89% for the Stage IB2 case with a CR, 74% for the Stage IIB case with a PR, and 57% for the Stage IIB case with a CR. When comparing MR- to CT-contoured CTV volumes, the higher level of agreement on CT may be due to the more distinct contrast visible on the images at the time of brachytherapy. The largest difference at the time of brachytherapy was in the case with parametrial extension at diagnosis that had a near-complete response, due to the appearance of the parametria on CT but not on MR. Based on these results, a 95% consensus volume was generated for CT and for MR. Online contouring atlases are available for instruction at http://www.nrgoncology.org/Resources/ContouringAtlases.aspx.
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影响因子：
10.6
作者：
Warfield, SK;Zou, KH;Wells, WM
通讯作者：
Wells, WM
影响因子：
2.5
作者：
Kapur, Tina;Egger, Jan;Damato, Antonio;Schmidt, Ehud J.;Viswanathan, Akila N.
通讯作者：
Viswanathan, Akila N.
DOI：
10.1016/j.ijrobp.2005.02.040
发表时间：
2005-07-01
影响因子：
7
作者：
Kirisits, C;Pötter, R;Georg, D
通讯作者：
Georg, D
影响因子：
3.8
作者：
Deasy, JO;Blanco, AI;Clark, VH
通讯作者：
Clark, VH
DOI：
10.1016/0360-3016(91)90143-r
发表时间：
1991-01-01
影响因子：
7
作者：
LANCIANO, RM;MARTZ, K;HANKS, GE
通讯作者：
HANKS, GE