3-T MR-guided brachytherapy for gynecologic malignancies.
3-T MR-guided brachytherapy for gynecologic malignancies.
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DOI：
10.1016/j.mri.2012.06.003
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发表时间：
2012-11
影响因子：
2.5
通讯作者：
Viswanathan, Akila N.
中科院分区：
文献类型：
--
作者：
Kapur, Tina;Egger, Jan;Damato, Antonio;Schmidt, Ehud J.;Viswanathan, Akila N.
妇科恶性肿瘤是全世界妇女死亡的主要原因。许多原发性和复发性妇科癌症病例的标准治疗包括外照射和近距离放射治疗的组合。磁共振成像（MRI）在诊断评估、绘制肿瘤位置以定制辐射剂量以及监测肿瘤对治疗的反应方面是有益的。妇科近距离放射治疗中MR引导的初步研究表明，能够优化肿瘤覆盖范围并减少对正常组织的辐射剂量，从而改善患者的结局。在这篇文章中，我们描述了一种方法，以帮助施源器放置和治疗计划的3特斯拉（3T）MR引导近距离放射治疗，是专门为妇科癌症。到目前为止，这已经在布莱根妇女医院的高级多模态图像引导手术套件中用于18例。它包括MR成像、图像分析和治疗计划的最新方法。在3T MR扫描中使用3D平衡稳态自由旋进的MR序列被确定为用于导管识别的最佳序列，头端有球囊伪影。使用MR图像进行3D治疗计划。正在开发的项目包括一个软件模块，旨在支持虚拟针轨迹规划，包括概率偏差校正、基于图形的分割和图像配准算法。结果表明，3T MR在妇科近距离放射治疗中有一定的应用价值。这些新的发展改善了对肿瘤的靶向治疗，同时保留了正常组织。
Gynecologic malignancies are a leading cause of death in women worldwide. Standard treatment for many primary and recurrent gynecologic cancer cases includes a combination of external beam radiation, followed by brachytherapy. Magnetic Resonance Imaging (MRI) is benefitial in diagnostic evaluation, in mapping the tumor location to tailor radiation dose, and in monitoring the tumor response to treatment. Initial studies of MR-guidance in gynecologic brachtherapy demonstrate the ability to optimize tumor coverage and reduce radiation dose to normal tissues, resulting in improved outcomes for patients. In this article we describe a methodology to aid applicator placement and treatment planning for 3 Tesla (3T) MR-guided brachytherapy that was developed specifically for gynecologic cancers. This has been used in 18 cases to date in the Advanced Multimodality Image Guided Operating suite at Brigham and Women’s Hospital. It is comprised of state of the art methods for MR imaging, image analysis, and treatment planning. An MR sequence using 3D-balanced steady state free precession in a 3T MR scan was identified as the best sequence for catheter identification with ballooning artifact at the tip. 3D treatment planning was performed using MR images. Item in development include a software module designed to support virtual needle trajectory planning that includes probabilistic bias correction, graph based segmentation, and image registration algorithms. The results demonstrate that 3T MR has a role in gynecologic brachytherapy. These novel developments improve targeted treatment to the tumor while sparing the normal tissues.
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DOI：
10.1016/j.ijrobp.2005.02.040
发表时间：
2005-07-01
影响因子：
7
作者：
Kirisits, C;Pötter, R;Georg, D
通讯作者：
Georg, D
影响因子：
10.9
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
19.7
作者：
Hricak, Hedvig;Gatsonis, Constantine;Mitchell, Donald G.
通讯作者：
Mitchell, Donald G.
影响因子：
5.7
作者：
Haack, Soren;Nielsen, Soren Kynde;Tanderup, Kari
通讯作者：
Tanderup, Kari