Externally sensitized deprotection of PPG-masked carbonyls as a spatial proximity probe in photoamplified detection of binding events.
Externally sensitized deprotection of PPG-masked carbonyls as a spatial proximity probe in photoamplified detection of binding events.
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DOI：
10.1039/c2pp05326h
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Kutateladze AG
中科院分区：
文献类型：
--
作者：
Gustafson TP;Metzel GA;Kutateladze AG
采用二噻烷PPG保护的羰基化合物的外敏化电子转移断裂来检测和扩增分子识别事件。新的方法允许检测低至50阿托摩尔的抗生物素蛋白利用成像器的基础上，低灵敏度的大规模生产的消费CCD相机。进行数值建模，以证明在表面上的2D放大的内在限制和无约束放大的优势，在一个分区体积的空间可寻址的3D解决方案。
Externally-sensitized electron-transfer fragmentation in dithiane PPG-protected carbonyls is adopted for detection and amplification of molecular recognition events. The new methodology allows for detection of as low as 50 attomoles of avidin utilizing an imager based on a low sensitivity mass-produced consumer CCD camera. Numeric modelling is carried out to demonstrate the intrinsic limitations of 2D amplification on surfaces and the advantages of unconstrained amplification in a compartmentalized volume of spatially addressable 3D solutions.
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影响因子：
41.2
作者：
Sikes, Hadley D.;Hansen, Ryan R.;Bowman, Christopher N.
通讯作者：
Bowman, Christopher N.
DOI：
10.1073/pnas.0606380103
发表时间：
2006-09-19
影响因子：
11.1
作者：
Kottani, Rudresha;Valiulin, Roman A.;Kutateladze, Andrei G.
通讯作者：
Kutateladze, Andrei G.
影响因子：
9.7
作者：
Avens, Heather J.;Bowman, Christopher N.
通讯作者：
Bowman, Christopher N.
影响因子：
3.8
作者：
Berron, Brad J.;Johnson, Leah M.;Ba, Xiao;McCall, Joshua D.;Alvey, Nicholas J.;Anseth, Kristi S.;Bowman, Christopher N.
通讯作者：
Bowman, Christopher N.
影响因子：
15
作者：
Gianneschi, NC;Nguyen, ST;Mirkin, CA
通讯作者：
Mirkin, CA