Multiparametric quantitative MRI for the evaluation of dysthyroid optic neuropathy
Multiparametric quantitative MRI for the evaluation of dysthyroid optic neuropathy
复制标题
多参数定量 MRI 评估甲状腺功能障碍性视神经病变
DOI：
10.1007/s00330-021-08300-2
复制
发表时间：
2021-10
影响因子：
5.9
通讯作者：
Zhiyun Yang
中科院分区：
文献类型：
--
作者：
Mengsha Zou;Dide Wu;Hongzhang Zhu;Xiahua Huang;Xiaojuan Zhao;Jing Zhao;Wenhao Fu;Ruocheng Li;Bin Li;Pengxia Wan;Shubin Hong;Yanbing Li;Haipeng Xiao;Zhiyun Yang
目的探讨MRI定量参数对甲状腺功能异常性视神经病变（DON）的预测价值。方法回顾性分析59例Graves眼眶病（GO）患者的临床资料和3.0T MRI资料，其中26例伴DON，33例不伴DON。我们比较了MRI定量参数，包括改良肌肉指数（mMI），突眼，眶内脂肪体积，平均表观扩散系数值，和T2值的视神经患者和非DON。进行逻辑回归分析以确定与DON相关的危险因素。此外，我们进行了接收机工作特性曲线分析和决策曲线分析，以评估DON.ResultsWe确定的参数的诊断性能进行了研究118轨道（43和75与和没有DON，分别）。视神经的mMI和平均T2值在有DON的眼眶中显著更大（p< 0.001）。在21 mm处更大的mMI（比值比（OR），1.039; 95%置信区间（CI）：1.019，1.058）和更高的视神经平均T2值（OR，1.035; 95% CI：1.017，1.054）与更高的DON风险相关。结合21 mm处mMI和视神经平均T2值的模型有效预测了GO患者的DON，灵敏度和特异性分别为95.3%和76%，结论结合21 mm处mMI和视神经平均T2值的MRI定量指标可作为诊断DON的有效影像学指标。GO和DON患者的mMI高于无DON的患者。DON患者的视神经显示T2值增加。·MRI定量参数结合21 mm处mMI和视神经平均T2值是诊断DON最有效的方法。
ObjectiveTo evaluate the ability of quantitative MRI parameters for predicting dysthyroid optic neuropathy (DON).MethodsWe retrospectively collected and analyzed the clinical features and 3.0 T MRI data of 59 patients with Graves orbitopathy (GO), with (n= 26) and without DON (n= 33). We compared MRI quantitative parameters, including the modified muscle index (mMI), proptosis, volume of intra-orbital fat, mean apparent diffusion coefficient value, and T2 value of the optic nerve among patients with and without DON. A logistic regression analysis was performed to identify the risk factors associated with DON. Moreover, we performed a receiver operating characteristic curve analysis and decision curve analysis to evaluate the diagnostic performance of the identified parameters for DON.ResultsWe studied 118 orbits (43 and 75 with and without DON, respectively). The mMI and mean T2 value of the optic nerve were significantly greater in orbits with DON (p< 0.001). A greater mMI at 21 mm (odds ratio (OR), 1.039; 95% confidence interval (CI): 1.019, 1.058) and higher mean T2 value of the optic nerve (OR, 1.035; 95% CI: 1.017, 1.054) were associated with a higher risk of DON. A model combining the mMI at 21 mm and mean T2 values for the optic nerve effectively predicted DON in patients with GO, with a sensitivity and specificity of 95.3% and 76%, respectively.ConclusionA quantitative MRI parameter combining the mMI at 21 mm and mean T2 value of the optic nerve can be an effective imaging marker for identifying DON.Key Points• Patients with GO and DON had greater mMI than those without DON.• Optic nerves in patients with DON demonstrated an increased T2 value.• The quantitative MRI parameter combining the mMI at 21 mm and mean T2 value of the optic nerve is the most effective method for diagnosing DON.
登录
查看更多内容
影响因子：
5.7
作者：
Kolbe, Scott;Chapman, Caron;Egan, Gary
通讯作者：
Egan, Gary
影响因子：
1.1
作者：
Garau LM;Guerrieri D;De Cristofaro F;Bruscolini A;Panzironi G
通讯作者：
Panzironi G
影响因子：
--
作者：
Jeon C;Shin JH;Woo KI;Kim YD
通讯作者：
Kim YD
影响因子：
5.9
作者：
Xiang Zhang;Fang Zhang;Liejing Lu;Haojiang Li;X. Wen;Jun Shen
通讯作者：
Xiang Zhang;Fang Zhang;Liejing Lu;Haojiang Li;X. Wen;Jun Shen
DOI：
10.1016/j.ajo.2005.06.012
发表时间：
2004-05
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
S. Hickman;C. Wheeler-Kingshott;Stephen J. Jones;K. Miszkiel;G. Barker;G. Plant;David H. Miller
通讯作者：
S. Hickman;C. Wheeler-Kingshott;Stephen J. Jones;K. Miszkiel;G. Barker;G. Plant;David H. Miller