Sex hormone-binding globulin gene expression and insulin resistance.
Sex hormone-binding globulin gene expression and insulin resistance.
复制标题
性激素结合球蛋白基因表达和胰岛素抵抗。
DOI：
10.1210/jc.2014-2640
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Dushan T. Ghooray
中科院分区：
文献类型：
--
作者：
S. Winters;J. Gogineni;Marjan Karegar;C. Scoggins;Chris A Wunderlich;R. Baumgartner;Dushan T. Ghooray
语境
性激素结合球蛋白 (SHBG) 是一种由肝细胞产生的糖蛋白，其血浆水平受到遗传、激素、代谢和营养的调节，是代谢综合征和糖尿病发生的标志物。
客观的
由于这些关联的机制尚不清楚，并且尚未发表有关人类 SHBG 基因表达的研究，因此在人类肝脏样本中测量了 SHBG mRNA 并与人体测量数据相关。
环境
研究人员对一家私立非营利性大学附属医院的住院患者进行了研究。
参加者
受试者为 55 名成年男性和女性，接受肝切除术治疗癌症。
主要成果指标
主要结果指标是 SHBG mRNA 和血清 SHBG 水平。
结果
SHBG mRNA 是血清 SHBG 的有力预测因子，女性的 mRNA 和蛋白质水平高于男性。 SHBG mRNA 与循环 SHBG 之间的关系在男性和女性中不同，这与转录后调节的性别差异一致。转录因子 HNF4α 的 mRNA 水平与 SHBG mRNA 水平之间存在很强的正相关性。通过稳态模型评估评估的胰岛素抵抗 (IR) 与 SHBG mRNA 和 HNF4α mRNA 以及循环 SHBG 水平呈负相关。当肝甘油三酯浓度较低时，这些 mRNA 以及血清 SHBG 较高，并随着体重指数的增加而降低，但与年龄无关。
结论
肝脏中的脂肪积累和 IR 是 SHBG 基因表达的重要决定因素，因此循环 SHBG 水平可能是通过对转录因子 HNF4α 的影响介导的。这些发现提供了一个潜在的机制来解释为什么低 SHBG 可以预测 2 型糖尿病的发展。
CONTEXT
The plasma level of sex hormone binding globulin (SHBG), a glycoprotein produced by hepatocytes, is subject to genetic, hormonal, metabolic, and nutritional regulation, and is a marker for the development of the metabolic syndrome and diabetes.
OBJECTIVE
Because the mechanism for these associations is unclear, and no studies of SHBG gene expression in humans have been published, SHBG mRNA was measured in human liver samples and related to anthropometric data.
SETTING
Inpatients at a private, nonprofit, university-associated hospital were studied.
PARTICIPANTS
Subjects were fifty five adult men and women undergoing hepatic resection as treatment for cancer.
MAIN OUTCOME MEASURES
Main outcome measures were SHBG mRNA and serum SHBG levels.
RESULTS
SHBG mRNA was a strong predictor of serum SHBG with higher levels of the mRNA and protein in women than in men. The relationship between SHBG mRNA and circulating SHBG differed in males and females consistent with a sex difference in post-transcriptional regulation. A strong positive correlation was found between the level of the mRNA for the transcription factor HNF4α and SHBG mRNA. Insulin resistance (IR), assessed by homeostatis model assessment, was related inversely to SHBG mRNA and to HNF4α mRNA as well as to circulating SHBG levels. These mRNAs, as well as serum SHBG, were higher when the hepatic triglyceride concentration was low, and decreased with increasing body mass index but were unrelated to age.
CONCLUSIONS
Fat accumulation in liver and IR are important determinants of SHBG gene expression and thereby circulating SHBG levels that are perhaps mediated through effects on the transcription factor HNF4α. These findings provide a potential mechanism to explain why low SHBG predicts the development of type 2 diabetes.
登录
查看更多内容
影响因子：
5.8
作者：
NESTLER, JE;POWERS, LP;BLACKARD, WG
通讯作者：
BLACKARD, WG
影响因子：
5.8
作者：
Hammoud, Ahmad;Gibson, Mark;Meikle, A. Wayne
通讯作者：
Meikle, A. Wayne
影响因子：
--
作者：
Xie, Xuefen;Liao, Hailing;Sladek, Frances M.
通讯作者：
Sladek, Frances M.
二氮嗪抑制血清胰岛素可降低患有多囊卵巢综合征的肥胖女性的血清睾酮水平。
DOI：
10.1210/jcem-68-6-1027
发表时间：
1989
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Nestler,JE;Barlascini,CO;Matt,DW;Steingold,KA;Plymate,SR;Clore,JN;Blackard,WG
通讯作者：
Blackard,WG
DOI：
10.1093/gerona/gls216
发表时间：
2013-06-01
影响因子：
5.1
作者：
Jasuja, Guneet Kaur;Travison, Thomas G.;Bhasin, Shalender
通讯作者：
Bhasin, Shalender