Chromophobe renal cell carcinoma with concomitant sarcomatoid transformation and osseous metaplasia: a case report.
Chromophobe renal cell carcinoma with concomitant sarcomatoid transformation and osseous metaplasia: a case report.
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DOI：
10.1186/1471-2490-13-72
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发表时间：
2013-12-13
期刊：
影响因子：
2
通讯作者：
Ohyama C
中科院分区：
文献类型：
--
作者：
Tanaka Y;Koie T;Hatakeyama S;Hashimoto Y;Ohyama C
肾嫌色细胞癌是成人肾上皮性肿瘤的第三大常见类型。肉瘤样成分发生在所有嫌色细胞肾细胞癌病例的约8%，而化生骨形成是极其罕见的。腹部计算机断层扫描显示右肾上极有一个2.5 × 2.3 cm的低血供肿瘤伴局灶性钙化。肿瘤临床诊断为右肾细胞癌，显示钙化的迹象，并进行腹腔镜下根治性右肾切除术。肿瘤的切面呈米色，表明肿瘤是一个广泛骨化的肿块。组织学分析显示肿瘤的三种不同形态成分。肾嫌色细胞癌由紧密的上皮细胞组成，排列成巢状，这些细胞与广泛的肉瘤样梭形细胞混合，具有明显的核多形性和活跃的有丝分裂活性。肿瘤还包含多个化生性骨化灶。肾嫌色细胞癌合并骨化生及肉瘤样转化是一种非常罕见的发生。
Chromophobe renal cell carcinoma is the third most common form of adult renal epithelial neoplasm. A sarcomatoid component occurs in approximately 8% of all chromophobe renal cell carcinoma cases, while metaplastic bone formation is extremely rare. An abdominal computed tomography scan revealed a hypovascular tumor with focal calcification, measuring 2.5 × 2.3 cm, in the upper pole of the right kidney. The tumor was clinically diagnosed as a right renal cell carcinoma that showed signs of calcification, and a laparoscopic right radical nephrectomy was performed. The cut surface of the tumor was beige in color and indicated that the tumor was an extensively ossified mass. Histological analysis revealed three distinct morphological components of the tumor. The chromophobe renal cell carcinoma consisted of compact epithelial cells arranged in a nested pattern, and these were mixed with extensive areas of sarcomatoid spindle cells with marked nuclear pleomorphism and brisk mitotic activity. The tumor also contained multiple foci of metaplastic ossification. Chromophobe renal cell carcinoma with concomitant osseous metaplasia and sarcomatoid transformation is a very rare occurrence.
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