Radiation-Related Alterations of Taste Function in Patients With Head and Neck Cancer: a Systematic Review.
Radiation-Related Alterations of Taste Function in Patients With Head and Neck Cancer: a Systematic Review.
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DOI：
10.1007/s11864-018-0580-7
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发表时间：
2018-11-09
影响因子：
4.3
通讯作者：
Frank SJ
中科院分区：
文献类型：
--
作者：
Deshpande TS;Blanchard P;Wang L;Foote RL;Zhang X;Frank SJ
味觉对健康的身体至关重要，因为它会影响我们的食物摄入量，作为一种防御机制和愉悦感。大多数接受放射治疗的头颈部癌症（HNC）患者患有味觉功能改变，经常抱怨无法品尝食物，食物摄入量减少和虚弱。然而，没有太多的研究来评估这种常见的副作用。此外，放射治疗引起的味觉改变的临床研究已被证明是困难的，考虑到缺乏可靠和有效的研究工具来评估客观和主观的结果。发展标准化的味觉功能评估工具，并在更大的HNC人群中进行前瞻性研究是时代的需要。味觉对于维持生命至关重要，我们需要专注于如何保护它。质子粒子的物理特性使辐射剂量精确定位到肿瘤，并将邻近健康组织的暴露降至最低。通过在HNC患者中使用强度调制质子治疗，我们预期通过减少对味蕾的辐射剂量来保护味觉。
Taste sensation is vital for a healthy body as it influences our food intake, acts as a defense mechanism and elicits pleasure. Majority of the head and neck cancer (HNC) patients undergoing radiotherapy suffer from altered taste function and often complain of inability to taste their food, reduced food intake, and weakness. However, there are not many studies conducted to assess this commonly reported side effect. Furthermore, clinical research on radiotherapy-induced taste alterations has proven to be difficult, considering a lack of reliable and validated study tools for assessing objective and subjective outcomes. Developing standardized tools for assessment of taste function and conducting prospective studies in larger population of HNC is the need of the hour. Taste sensation being critically important for sustenance, we need to focus on ways to preserve it. The physical properties of proton particle enable localization of the radiation dose precisely to the tumor and minimizing the exposure of the adjacent healthy tissues. By using Intensity-Modulated Proton Therapy in HNC patients, we anticipate preserving the taste sensation by reducing the dose of radiation to the taste buds.
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影响因子：
15.8
作者：
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通讯作者：
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