Ginsenoside Rg1 Ameliorates Neuroinflammation via Suppression of Connexin43 Ubiquitination to Attenuate Depression.
Ginsenoside Rg1 Ameliorates Neuroinflammation via Suppression of Connexin43 Ubiquitination to Attenuate Depression.
复制标题
人参皂苷 Rg1 通过抑制 Connexin43 泛素化来减轻抑郁症，从而改善神经炎症
DOI：
10.3389/fphar.2021.709019
复制
发表时间：
2021
影响因子：
5.6
通讯作者：
Chen N
中科院分区：
文献类型：
--
作者：
Wang H;Yang Y;Yang S;Ren S;Feng J;Liu Y;Chen H;Chen N
抑郁症是一种炎症相关疾病，随着炎症的增加和进展，会导致重度抑郁症。人参皂苷Rg 1（Ginsenoside Rg 1，Rg 1）是人参的主要生物活性成分，具有显著的抗炎、抗炎作用。我们前期的研究表明，抑郁症的发病机制是伴随着连接蛋白43（Cx43）泛素降解的加速，而Rg 1可以通过上调Cx43的表达来减轻抑郁症。然而，Cx43的泛素化是否是抑郁症和炎症之间的特定相关性，以及Rg 1如何改善神经炎症以减轻抑郁症，仍在研究中。在体内实验中，人参皂甙1治疗显着改善抑郁样行为大鼠进行慢性不可预测的压力（CUS）。此外，这些CUS大鼠与Rg 1治疗表现出减弱的神经炎症，连同Cx43泛素化的抑制。在体外实验中，Rg 1减少了脂多糖诱导的神经胶质细胞中炎性细胞因子的分泌和Cx43的泛素化。此外，用泛素-蛋白酶体抑制剂MG 132抑制Cx43的泛素化可改善脂多糖诱导的神经炎症。结果表明，Rg 1减弱抑郁样行为表现在暴露于氚的大鼠;和Rg 1的抗抑郁样作用的主要机制似乎涉及通过抑制Cx43泛素化对神经炎症的保护。结论：Rg 1可通过抑制Cx43泛素化而减轻神经炎症，从而减轻抑郁症，这为Rg 1治疗炎症相关抑郁症提供了新的思路。
Depression is an inflammation-associated disease that results in major depression as inflammation increases and progresses. Ginsenoside Rg1 (Rg1), the major bioactive ingredient derived from ginseng, possesses remarkable anti-depressant and anti-inflammatory effects. Our previous studies showed that the pathogenesis of depression was concomitant with the acceleration of connexin43 (Cx43) ubiquitin degradation, while Rg1 could upregulate Cx43 expression to attenuate depression. However, whether the ubiquitination of Cx43 is the specific correlation between depression and inflammation, and how Rg1 ameliorates neuroinflammation to attenuate depression, are still under investigation. In in vivo experiments, Rg1 treatment significantly ameliorated depression-like behaviors in rats subjected to chronic unpredictable stress (CUS). Moreover, these CUS rats treated with Rg1 exhibited attenuated neuroinflammation, together with the suppression of Cx43 ubiquitination. In in vitro experiments, Rg1 reduced the secretion of inflammatory cytokines and the ubiquitination of Cx43 in lipopolysaccharide-induced glial cells. Furthermore, treatment with ubiquitin-proteasome inhibitor MG132 suppressing the ubiquitination of Cx43 ameliorated lipopolysaccharide-induced neuroinflammation. The results suggest that Rg1 attenuates depression-like behavioral performances in CUS-exposed rats; and the main mechanism of the antidepressant-like effects of Rg1 appears to involve protection against neuroinflammation via suppression of Cx43 ubiquitination. In conclusion, Rg1 could ameliorate neuroinflammation via suppression of Cx43 ubiquitination to attenuate depression, which represents the perspective of an innovative therapy of Rg1 in the treatment of inflammation-associated depression.
登录
查看更多内容
影响因子：
6.1
作者：
Jiang, Ning;Lv, Jingwei;Liu, Xin-min
通讯作者：
Liu, Xin-min
慢性不可预测应激引起的抑郁小鼠模型中小胶质细胞刺激的抗抑郁特性
DOI：
10.1016/j.pnpbp.2020.109931
发表时间：
2020-07-13
影响因子：
5.6
作者：
Cai, Zixuan;Ye, Ting;Huang, Chao
通讯作者：
Huang, Chao
影响因子：
32.4
作者：
Schmid D;Münz C
通讯作者：
Münz C
影响因子：
10.6
作者：
Boland, Barry;Nixon, Ralph A.
通讯作者：
Nixon, Ralph A.
炎症：抑郁症迷在高温下火焰和盛宴。
DOI：
10.1176/appi.ajp.2015.15020152
发表时间：
2015-11-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Kiecolt-Glaser JK;Derry HM;Fagundes CP
通讯作者：
Fagundes CP