Inflammation: depression fans the flames and feasts on the heat.
Inflammation: depression fans the flames and feasts on the heat.
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炎症：抑郁症迷在高温下火焰和盛宴。
DOI：
10.1176/appi.ajp.2015.15020152
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发表时间：
2015-11-01
期刊：
影响因子：
--
通讯作者：
Fagundes CP
中科院分区：
文献类型：
--
作者：
Kiecolt-Glaser JK;Derry HM;Fagundes CP
抑郁症和炎症是相互促进的。炎症在抑郁症的发病机制中起着关键作用，抑郁症也引发了更大的细胞因子对压力源和病原体的反应，这些压力源和病原体似乎并不习惯。因此，治疗决定可能会被告知注意的问题“如何”（途径）和“为谁”（倾向）这些联系存在，这是当前文章的重点。当与诱发因素（如童年逆境和肥胖等调节因素）相结合时，压力源和病原体可能导致夸大或延长炎症反应。由此产生的疾病行为（例如，疼痛，睡眠紊乱），抑郁症状，和消极的健康行为（例如，不良的饮食习惯，久坐不动的生活方式）可能作为介导途径，导致进一步的无限制炎症和抑郁症。抑郁症，童年逆境，压力源和饮食都可以影响肠道微生物组并促进肠道通透性，这是增强炎症反应的另一种途径。更大、更频繁或更长时间的炎症反应可能会对身心健康产生负面影响。在临床实践中，炎症通过对某些治疗策略的信号响应性提供了症状管理的潜在靶点的指导。例如，在细胞因子拮抗剂、omega-3多不饱和脂肪酸、塞来昔布和运动的研究中，一个主题是抗炎干预对炎症加剧的个体的情绪有更大的影响。因此，当炎症和抑郁症同时发生时，同时治疗它们可以促进恢复并降低复发的风险。抑郁症、炎症和疾病之间的双向联系表明，有效的抑郁症治疗可能对情绪、炎症和健康产生深远的影响。
Depression and inflammation fuel one another. Inflammation plays a key role in depression’s pathogenesis for a subset of depressed individuals; depression also primes larger cytokine responses to stressors and pathogens that do not appear to habituate. Accordingly, treatment decisions may be informed by attention to questions of ‘how’ (pathways) and ‘for whom’ (predispositions) these links exist, which are the focus of the current article. When combined with predisposing factors (moderators such as childhood adversity and obesity), stressors and pathogens can lead to exaggerated or prolonged inflammatory responses. The resulting sickness behaviors (e.g., pain, disturbed sleep), depressive symptoms, and negative health behaviors (e.g., poor diet, a sedentary lifestyle) may act as mediating pathways that lead to further unrestrained inflammation and depression. Depression, childhood adversity, stressors, and diet can all influence the gut microbiome and promote intestinal permeability, another pathway to enhanced inflammatory responses. Larger, more frequent, or more prolonged inflammatory responses could have negative mental and physical health consequences. In clinical practice, inflammation provides a guide to potential targets for symptom management by signaling responsiveness to certain therapeutic strategies. For example, a theme across research with cytokine antagonists, omega-3 polyunsaturated fatty acids, celecoxib, and exercise is that anti-inflammatory interventions have a substantially greater impact on mood among individuals with heightened inflammation. Thus, when inflammation and depression co-occur, treating them in tandem may enhance recovery and reduce risk of recurrence. The bidirectional links among depression, inflammation, and disease suggest that effective depression treatments could have a far-reaching impact on mood, inflammation, and health.
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DOI：
10.1038/npp.2010.159
发表时间：
2010-12
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
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作者：
通讯作者：
--
影响因子：
11
作者：
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作者：
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影响因子：
3.7
作者：
Bower JE;Greendale G;Crosswell AD;Garet D;Sternlieb B;Ganz PA;Irwin MR;Olmstead R;Arevalo J;Cole SW
通讯作者：
Cole SW
影响因子：
29
作者：
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