Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women.
Plasma 25-hydroxyvitamin D concentrations and periodontal disease in postmenopausal women.
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DOI：
10.1902/jop.2012.120445
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发表时间：
2013-09
影响因子：
4.3
通讯作者：
Wactawski-Wende J
中科院分区：
文献类型：
--
作者：
Millen AE;Hovey KM;LaMonte MJ;Swanson M;Andrews CA;Kluczynski MA;Genco RJ;Wactawski-Wende J
维生素 D 具有抗炎和抗微生物特性，再加上其对骨骼健康的影响，可能对牙周有益。我们调查了 920 名绝经后妇女血浆 25-羟基维生素 D 浓度 [25(OH)D] 与牙周测量之间的横断面关联性 (1997-2000)。慢性疾病测量的定义基于：1) 口内 X 光片和牙齿脱落的牙槽嵴高度 (ACH) 测量，以及 2) 疾病控制和预防中心 (CDC)/美国牙周病学会 (AAP) 标准，使用临床附着水平 (CAL) 和探诊牙周袋深度 (PD) 测量。通过探针评估时出血的牙龈部位的百分比来评估急性口腔炎症。使用 Logistic 回归来估计维生素 D 充足 ([25(OH)D]≥50 nmol/L) 与缺乏/不足 ([25(OH)D]<50 nmol/L) 维生素 D 状态的参与者的比值比 (OR) 和 95% 置信区间 (CI)，并根据年龄、牙科就诊频率和体重指数进行调整。未观察到维生素 D 状态与 ACH 定义的牙周病和牙齿脱落之间存在关联（调整后 OR=0.96，95% CI：0.68–1.35）。相比之下，与维生素 D 缺乏/不足的女性相比，维生素 D 水平充足的女性患使用 CDC/AAP 定义定义的牙周病的几率要低 33% (95% CI: 5%–53%)，并且 ≥50% 牙龈部位出血的几率要低 42% (95% CI: 21%-58%)。维生素 D 状态与牙龈出血（口腔健康和炎症的一项急性指标）呈负相关，并且与包含 PD（口腔炎症指标）的慢性牙周病的临床类别呈负相关。然而，根据 ACH 与牙齿脱落的测量结果，维生素 D 与慢性牙周病无关。
Vitamin D has anti-inflammatory and anti-microbial properties that, together with its influence on bone health, may confer periodontal benefit. We investigated cross-sectional associations (1997–2000) between plasma 25-hydroxyvitamin D concentrations [25(OH)D] and periodontal measure among 920 postmenopausal women. Chronic measures of disease were defined based on: 1) alveolar crestal height (ACH) measures from intraoral radiographs and tooth loss, and the 2) Center for Disease Control and Prevention (CDC)/American Academy of Periodontology (AAP) criteria using measures of clinical attachment level (CAL) and probing pocket depth (PD). Acute oral inflammation was assessed by the % of gingival sites that bled upon assessment with a probe. Logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CIs) for periodontal disease among participants with adequate ([25(OH)D]≥50 nmol/L) compared to deficient/inadequate ([25(OH)D]<50 nmol/L) vitamin D status adjusted for age, dental visit frequency, and body mass index. No association was observed between vitamin D status and periodontal disease defined by ACH and tooth loss (adjusted OR=0.96, 95% CI: 0.68–1.35). In contrast, women with adequate compared to deficient/inadequate vitamin D status had a 33% lower odds (95% CI: 5%–53%) of periodontal disease defined using the CDC/AAP definition and a 42% lower odds (95% CI: 21%-58%) of having ≥50% of gingival sites that bled. Vitamin D status was inversely associated with gingival bleeding, an acute measure of oral health and inflammation and inversely associated with clinical categories of chronic periodontal disease that incorporated PD, an indicator of oral inflammation. However, vitamin D was not associated with chronic periodontal disease based on measures of ACH in combination with tooth loss.
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影响因子：
7.6
作者：
BONTA, Y;ZAMBON, JJ;NEIDERS, ME
通讯作者：
NEIDERS, ME
影响因子：
5.6
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影响因子：
4.4
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影响因子：
4.3
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Trevisan, M