Imaging neural architecture of the brain based on its multipole magnetic response.
Imaging neural architecture of the brain based on its multipole magnetic response.
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DOI：
10.1016/j.neuroimage.2012.10.050
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发表时间：
2013-02-15
期刊：
影响因子：
5.7
通讯作者：
Li, Wei
中科院分区：
文献类型：
--
作者：
Liu, Chunlei;Li, Wei
虽然磁场与生物组织的相互作用很弱，但在高磁场下，这种相互作用足够强，足以导致各种组织类型之间的拉莫尔频率发生可测量的变化。虽然测量频移及其各向异性使NMR光谱能够确定大分子的结构，但MRI还不能充分利用频率中存在的大量信息来阐明组织的微观结构。使用多极分析的复杂的MRI信号在傅立叶频谱空间中，我们开发了一种快速和高分辨率的方法，使组织的磁响应的量化与一组不同等级的磁化率张量。傅立叶频谱空间，称为p空间，可以通过施加场梯度或等效地通过在各个方向上移动k空间数据来生成。测量这些张量允许组织结构的可视化和量化。我们进行了三维全脑多极磁化率张量成像模拟，完整的小鼠大脑离体和人脑在体内。我们发现，这些多极磁化率张量可以用来成像有序的白色物质纤维的取向。这些实验表明，多极张量分析可以实现在体内组织微观结构的实际映射，而无需旋转主体或磁场。
Although magnetic fields interact weakly with biological tissues, at high fields, this interaction is sufficiently strong to cause measurable shifts in the Larmor frequency among various tissue types. While measuring frequency shift and its anisotropy has enabled NMR spectroscopy to determine structures of large molecules, MRI has not been able to fully utilize the vast information existing in the frequency to elucidate tissue microstructure. Using a multipole analysis of the complex MRI signal in the Fourier spectral space, we developed a fast and high-resolution method that enables the quantification of tissue’s magnetic response with a set of magnetic susceptibility tensors of various ranks. The Fourier spectral space, termed p-space, can be generated by applying field gradients or equivalently by shifting the k-space data in various directions. Measuring these tensors allows the visualization and quantification of tissue architecture. We performed 3D whole-brain multipole susceptibility tensor imaging in simulation, on intact mouse brains ex vivo and on human brains in vivo. We showed that these multipole susceptibility tensors can be used to image orientations of ordered white matter fibers. These experiments demonstrate that multipole tensor analysis may enable practical mapping of tissue microstructure in vivo without rotating subject or magnetic field.
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影响因子：
5.7
作者：
Liu, Chunlei;Li, Wei;Wu, Bing;Jiang, Yi;Johnson, G. Allan
通讯作者：
Johnson, G. Allan
DOI：
10.1073/pnas.92.20.9279
发表时间：
1995-09-26
影响因子：
11.1
作者：
TOLMAN, JR;FLANAGAN, JM;PRESTEGARD, JH
通讯作者：
PRESTEGARD, JH
影响因子：
3.3
作者：
Li, L
通讯作者：
Li, L
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
DOI：
10.1073/pnas.0910222107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Lee, Jongho;Shmueli, Karin;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.