3D fiber tractography with susceptibility tensor imaging.
3D fiber tractography with susceptibility tensor imaging.
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DOI：
10.1016/j.neuroimage.2011.07.096
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发表时间：
2012-01-16
期刊：
影响因子：
5.7
通讯作者：
Johnson, G. Allan
中科院分区：
文献类型：
--
作者：
Liu, Chunlei;Li, Wei;Wu, Bing;Jiang, Yi;Johnson, G. Allan
关键词：
磁共振成像显示大脑白色物质的磁化率各向异性。这种磁化率各向异性可以通过磁化率张量成像（STI）来测量和表征。在这项研究中，提出了一种基于STI的纤维束成像方法，并在小鼠脑中进行了演示。在7.0T下进行灌流固定的小鼠脑的STI实验。利用正则化方法计算每个体素的磁化率张量，并将其分解为特征系统。主要的特征向量被认为是与底层的纤维取向对齐。根据主要特征向量的方向，我们能够在3D中映射不同的纤维路径。作为比较，在相同的标本上也进行了扩散张量成像（DTI）和DTI纤维束成像。STI和DTI纤维束之间的关系进行了探讨，确定的异同。STI纤维束成像技术有望为研究白色物质纤维构筑提供新的途径。由于STI纤维束成像基于与DTI根本不同的物理原理，因此它也可能对DTI纤维束成像的持续验证有价值。
Gradient-echo MRI has revealed anisotropic magnetic susceptibility in the brain white matter. This magnetic susceptibility anisotropy can be measured and characterized with susceptibility tensor imaging (STI). In this study, a method of fiber tractography based on STI is proposed and demonstrated in the mouse brain. STI experiments of perfusion-fixed mouse brains were conducted at 7.0 T. The magnetic susceptibility tensor was calculated for each voxel with regularization and decomposed into its eigensystem. The major eigenvector is found to be aligned with the underlying fiber orientation. Following the orientation of the major eigenvector, we are able to map distinctive fiber pathways in 3D. As a comparison, diffusion tensor imaging (DTI) and DTI fiber tractography were also conducted on the same specimens. The relationship between STI and DTI fiber tracts was explored with similarities and differences identified. It is anticipated that the proposed method of STI tractography may provide a new way to study white matter fiber architecture. As STI tractography is based on physical principles that are fundamentally different from DTI, it may also be valuable for the ongoing validation of DTI tractography.
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DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
DOI：
10.1073/pnas.0910222107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Lee, Jongho;Shmueli, Karin;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
2.7
作者：
OTTING G;LIEPINSH E;WUTHRICH K
通讯作者：
WUTHRICH K
DOI：
10.1002/cmr.b.10083
发表时间：
2003-10-01
影响因子：
0.9
作者：
Salomir, R;De Senneville, BD;Moonen, CTW
通讯作者：
Moonen, CTW
影响因子：
5.7
作者：
Liu, Chunlei;Li, Wei;Johnson, G. Allan;Wu, Bing
通讯作者：
Wu, Bing