Alcohol use disorder as a potential risk factor for COVID-19 severity: A narrative review.
Alcohol use disorder as a potential risk factor for COVID-19 severity: A narrative review.
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DOI：
10.1111/acer.14936
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发表时间：
2022-11
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
2019年12月至2020年1月，一种起源于中国武汉的肺炎疾病被指定为2019年冠状病毒病（COVID-19），被证明是由一种新型RNA冠状病毒引起的，称为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。高龄、男性和/或潜在健康状况（肥胖、2型糖尿病、心血管疾病、高血压、慢性肾病和慢性肺病）的人特别容易出现严重的COVID-19症状和死亡。这些风险因素会影响免疫系统，也与健康状况不佳，慢性疾病和寿命缩短有关。然而，很大一部分没有这些已知风险因素的患者也会发展为严重的COVID-19疾病，包括死亡。因此，必须存在新的风险因素，促进对SARS-CoV-2病毒的过度炎症和免疫反应，导致死亡。其中一个风险因素可能是酒精滥用和酒精使用障碍（AUD），因为这些会加剧病毒性肺部感染，如SARS，流感和肺炎。因此，酒精滥用可能是个体暴露于SARS-CoV-2病毒时感染率增加的风险因素和/或感染患者中更严重的COVID-19的风险因素，这是非常合理的。酒精使用是SARS患者肺部疾病和ARDS的一个众所周知的危险因素。我们认为酒精与其他COVID-19严重风险因素有几个共同的关键致病因素。这三个关键因素是炎性微生物群生态失调、肠漏和NLRP 3炎性体的全身激活。我们还提出这三个要素代表了严重COVID-19治疗的目标。
In Dec. 2019-January 2020 a pneumonia illness originating in Wuhan, China designated as coronavirus disease 2019 (COVID-19) was shown to be caused by a novel RNA coronavirus designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). People with advanced age, male sex, and/or underlying health conditions (obesity, type 2 diabetes, cardiovascular disease, hypertension, chronic kidney disease, and chronic lung disease) are especially vulnerable to severe COVID-19 symptoms and death. These risk factors impact the immune system and are also associated with poor health, chronic illness, and shortened longevity. However, a large percent of patients without these known risk factors also develop severe COVID-19 disease including death. Thus, new risk factors that promote exaggerated inflammatory and immune response to the SARS-CoV-2 virus leading to death must exist. One such risk factor may be alcohol misuse and alcohol use disorder (AUD) because these can exacerbate viral lung infections like SARS and flu and pneumonia. Thus, it is highly plausible that alcohol misuse would be a risk factor for either increased infection rate when individuals are exposed to SARS-CoV-2 virus and/or a risk factor for more severe COVID-19 in infected patients. Alcohol use is a well-known risk factor for lung diseases and ARDS in SARS patients. We propose alcohol has several key pathogenic elements in common with other COVID-19 severity risk factors. These three key elements are inflammatory microbiota dysbiosis, leaky gut and systemic activation of the NLRP3 inflammasome. We also propose these three elements represent targets for therapy for severe COVID-19.
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DOI：
10.1016/j.alcohol.2020.10.003
发表时间：
2021-03
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Bailey KL;Samuelson DR;Wyatt TA
通讯作者：
Wyatt TA
影响因子：
4.6
作者：
Bugyei-Twum A;Abadeh A;Thai K;Zhang Y;Mitchell M;Kabir G;Connelly KA
通讯作者：
Connelly KA
胃肠道症状预测了Covid-19感染的结果。
影响因子：
2.9
作者：
Bishehsari F;Adnan D;Deshmukh A;Khan SR;Rempert T;Dhana K;Mahdavinia M
通讯作者：
Mahdavinia M
DOI：
10.1111/j.1530-0277.2010.01259.x
发表时间：
2010-10
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Boé DM;Richens TR;Horstmann SA;Burnham EL;Janssen WJ;Henson PM;Moss M;Vandivier RW
通讯作者：
Vandivier RW
影响因子：
5.8
作者：
Campbell GR;To RK;Hanna J;Spector SA
通讯作者：
Spector SA