Impact of body mass and alcohol consumption on all-cause and liver mortality in 240 000 adults in the United States.
Impact of body mass and alcohol consumption on all-cause and liver mortality in 240 000 adults in the United States.
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DOI：
10.1111/dar.13265
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发表时间：
2021-09
影响因子：
3.8
通讯作者：
Rehm, Jurgen
中科院分区：
文献类型：
--
作者：
Patra, Jayadeep;Buckley, Charlotte;Kerr, William C.;Brennan, Alan;Purshouse, Robin C.;Rehm, Jurgen
目前尚无关于饮酒和体重 (BMI) 对死亡率结果综合影响的全国代表性研究。我们研究两者共同作用是否会增加全因死亡率或肝脏死亡率的风险。我们从 1997 年至 2004 年国家健康访谈调查中采访了 129 098 名女性（平均年龄 47.2 岁）和 102 568 名≥18 岁的男性（平均年龄 45.6 岁），他们获得了自我报告的饮酒史和体重指数，并将这些数据与截至 2006 年 12 月 31 日发生的死亡人数相关联（女性 = 8486；男性 = 7819）死亡）。不同体重指数组中当前饮酒者的死亡风险根据年龄、教育程度、种族和吸烟情况进行了调整。肥胖（≥30 kg m−2）成人摄入>40 g day−1（女性）或>60 g day−1（男性）纯乙醇，有因全因和慢性肝病导致死亡率增加的风险（P 趋势<0.0001）。对于BMI≥30 kg m−2的重度饮酒者来说，BMI每升高5 kg m−2，男性（风险比1.27，95%置信区间[CI]：1.16–1.40）和女性（1.12，[1.02–1.24]）的全因死亡率升高相关。男性 (7.30, [3.60–11.00]) 中因相互作用而导致的超额风险比女性 (2.90, [0.50–5.30]) 更为明显。肥胖和过量饮酒都与全因死亡率和肝脏死亡率有关——后者有证据表明危险因素之间存在超加性相互作用。这两个因素在同一人群中的存在及其影响应该为治疗、公共卫生政策和研究提供信息。
Nationally representative studies of the combined impact of drinking and body mass (BMI) on mortality outcomes are unavailable. We investigate whether both act together to elevate risk of all-cause or liver mortality. We obtained self-reported histories of drinking and BMI from 129 098 women (mean age 47.2 years) and 102 568 men (mean age 45.6 years) ≥18 years interviewed from 1997 to 2004 in the National Health Interview Survey and related these data to the deaths that occurred by 31 December 2006 (women = 8486; men = 7819 deaths). Death hazards among current drinkers in different BMI groups were adjusted for age, education, race and smoking. Obese (≥30 kg m−2) adults with consumption of >40 g day−1 (women) or >60 g day−1 (men) pure ethanol were at risk of increased mortality from all-cause and chronic liver disease (P trend <0.0001). For heavy drinkers with BMI ≥30 kg m−2, each 5 kg m−2 higher BMI was associated with an elevated all-cause mortality in men (hazard ratios 1.27, 95% confidence interval [CI]: 1.16–1.40) and women (1.12, [1.02–1.24]). The excess risk due to interaction was more pronounced in men (7.30, [3.60–11.00]) than women (2.90, [0.50–5.30]). Obesity and excess alcohol are both related to all-cause and liver mortality—the latter with evidence of a supra-additive interaction between the risk factors. The presence of both factors in the same population and their impact should inform treatment, public health policies and research.
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影响因子：
8.8
作者：
Inoue Y;Qin B;Poti J;Sokol R;Gordon-Larsen P
通讯作者：
Gordon-Larsen P
影响因子：
13.6
作者：
Andersson, T;Alfredsson, L;Ahlbom, A
通讯作者：
Ahlbom, A
影响因子：
19.6
作者：
de Mutsert, Renee;Jager, Kitty J.;Dekker, Friedo W.
通讯作者：
Dekker, Friedo W.
DOI：
10.1136/bmj.c1240
发表时间：
2010-03-11
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Hart CL;Morrison DS;Batty GD;Mitchell RJ;Davey Smith G
通讯作者：
Davey Smith G
影响因子：
7.6
作者：
Loomba R;Bettencourt R;Barrett-Connor E
通讯作者：
Barrett-Connor E