Phase Variation During Host Colonization and Invasion by Campylobacter jejuni and Other Campylobacter Species.
Phase Variation During Host Colonization and Invasion by Campylobacter jejuni and Other Campylobacter Species.
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DOI：
10.3389/fmicb.2021.705139
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发表时间：
2021
影响因子：
5.2
通讯作者：
Bayliss CD
中科院分区：
文献类型：
--
作者：
Cayrou C;Barratt NA;Ketley JM;Bayliss CD
相变化（PV）是一种常见的现象，各种细菌物种的生态位适应和生存在挑战性的环境。在弯曲杆菌属物种中，PV取决于基因间和基因内高变G/C均聚物区的存在。相位可变基因的存在对于引起人类食源性或人畜共患病感染的物种特别感兴趣。PV影响弯曲杆菌属中脂寡糖、鞭毛和荚膜的形成和结构。这些分子的组分的PV在侵入宿主组织、在宿主内传播和在宿主之间传播过程中具有潜在的重要性。运动性是一种重要的表型，可能受PV调节。在鸡和小鼠感染模型的定殖过程中，观察到相变量基因的状态发生变化。有趣的是，PV也参与了噬菌体攻击的细菌存活，甚至在鸡定殖期间。本文旨在探讨和讨论观察PV模型和自然感染的弯曲杆菌物种和PV如何可能影响战略对抗这种食源性病原体感染。
Phase variation (PV) is a phenomenon common to a variety of bacterial species for niche adaption and survival in challenging environments. Among Campylobacter species, PV depends on the presence of intergenic and intragenic hypermutable G/C homopolymeric tracts. The presence of phase-variable genes is of especial interest for species that cause foodborne or zoonotic infections in humans. PV influences the formation and the structure of the lipooligosaccharide, flagella, and capsule in Campylobacter species. PV of components of these molecules is potentially important during invasion of host tissues, spread within hosts and transmission between hosts. Motility is a critical phenotype that is potentially modulated by PV. Variation in the status of the phase-variable genes has been observed to occur during colonization in chickens and mouse infection models. Interestingly, PV is also involved in bacterial survival of attack by bacteriophages even during chicken colonization. This review aims to explore and discuss observations of PV during model and natural infections by Campylobacter species and how PV may affect strategies for fighting infections by this foodborne pathogen.
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影响因子：
3.9
作者：
Aidley J;Wanford JJ;Green LR;Sheppard SK;Bayliss CD
通讯作者：
Bayliss CD
影响因子：
5.7
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Guerry P;Poly F;Riddle M;Maue AC;Chen YH;Monteiro MA
通讯作者：
Monteiro MA
影响因子：
6.4
作者：
Aidley J;Rajopadhye S;Akinyemi NM;Lango-Scholey L;Jones MA;Bayliss CD
通讯作者：
Bayliss CD
影响因子：
5.6
作者：
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通讯作者：
Muggleton, Stephen H.
影响因子：
4.5
作者：
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通讯作者：
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