Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.
Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.
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DOI：
10.1126/science.1192020
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发表时间：
2010-09-24
期刊：
影响因子：
--
通讯作者：
Iino Y
中科院分区：
文献类型：
--
作者：
Yamada K;Hirotsu T;Matsuki M;Butcher RA;Tomioka M;Ishihara T;Clardy J;Kunitomo H;Iino Y
种群密度依赖性扩散是一种具有良好特征的动物行为策略，种群密度越高，扩散率越高。秀丽隐杆线虫对一组气味剂表现出正向趋化性，但在长时间暴露于气味剂后，趋化性从吸引转变为分散。我们在这里表明，嗅觉行为的可塑性依赖于种群密度，这种调节是由信息素信号介导的。我们发现肽SNET-1负向调节嗅觉可塑性，其表达被信息素下调。NEP-2是细胞外肽酶neprilysin的同源物，可拮抗SNET-1，该功能对嗅觉可塑性至关重要。这些结果表明，种群密度信息通过外部信息素和内源性肽信号传递来调节趋化行为。
Population density-dependent dispersal is a well-characterized strategy of animal behavior in which dispersal rate increases when population density is higher. C. elegans shows positive chemotaxis to a set of odorants, but the chemotaxis switches from attraction to dispersal after prolonged exposure to the odorants. We show here that this plasticity of olfactory behavior is dependent on population density and this regulation is mediated by pheromonal signaling. We show that a peptide SNET-1 negatively regulates olfactory plasticity and its expression is down-regulated by the pheromone. NEP-2, a homologue of the extracellular peptidase neprilysin, antagonizes SNET-1 and this function is essential for olfactory plasticity. These results suggest that population density information is transmitted through the external pheromone and endogenous peptide signaling to modulate chemotactic behavior.
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影响因子：
64.5
作者：
BARGMANN, CI;HARTWIEG, E;HORVITZ, HR
通讯作者：
HORVITZ, HR
影响因子：
3.3
作者：
Yamada, Koji;Hirotsu, Takaaki;Iino, Yuichi
通讯作者：
Iino, Yuichi
DOI：
10.1073/pnas.191352498
发表时间：
2001-09-25
影响因子：
11.1
作者：
Peckol, EL;Troemel, ER;Bargmann, CI
通讯作者：
Bargmann, CI
影响因子：
3.5
作者：
DEVAULT, A;SALES, V;BOILEAU, G
通讯作者：
BOILEAU, G
影响因子：
64.8
作者：
Jeong, PY;Jung, M;Paik, YK
通讯作者：
Paik, YK