The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span.
The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span.
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DOI：
10.1371/journal.pone.0056733
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Salat DH
中科院分区：
文献类型：
--
作者：
Chen JJ;Rosas HD;Salat DH
大脑白色物质的退化通常在衰老中观察到，并且神经连接的相关退化有助于老年人的认知能力下降。血管功能障碍已被认为是一般年龄相关的神经组织退化的潜在机制;然而，没有先前的研究已经检查了皮质血管健康和皮质下白质完整性之间的直接关系。在这项工作中，我们的目的是确定大脑的血液供应是否与结缔组织的微结构完整性有关，以及这种关联是否具有区域特异性，主要是由衰老引起的。我们研究了一组健康成年人从成年早期到成年晚期的大脑皮质套中的脑血流量（CBF）（使用动脉自旋标记（ASL）测量）和皮质下白质完整性（使用扩散张量成像（DTI）测量）之间的相关性。我们发现皮质CBF与整个大脑的白质完整性显著相关。此外，这些关联仅部分与衰老有关，因为即使在统计学上控制年龄，并且将分析限制在样本的年轻子集时，它们仍然存在。此外，血管风险不是这些影响的主要决定因素。这些研究结果表明，大脑的总体血液供应是成年人正常变化范围内白质健康的重要指标，并且随着年龄的增长，CBF的下降可能会加剧大脑结缔组织解剖结构的恶化。
Degeneration of cerebral white matter is commonly observed in aging, and the associated degradation in neural connectivity contributes to cognitive decline in older adults. Vascular dysfunction has been implicated as a potential mechanism for general age-related neural tissue deterioration; however, no prior study has examined the direct relationship between cortical vascular health and subcortical white-matter integrity. In this work, we aimed to determine whether blood supply to the brain is associated with microstructural integrity of connective tissue, and whether such associations are regionally specific and mainly accounted for by aging. We examined the association between cerebral blood flow (CBF) in the cortical mantle, measured using arterial spin labeling (ASL), and subcortical white-matter integrity, measured using diffusion tensor imaging (DTI), in a group of healthy adults spanning early to late adulthood. We found cortical CBF to be significantly associated with white-matter integrity throughout the brain. In addition, these associations were only partially tied to aging, as they remained even when statistically controlling for age, and when restricting the analyses to a young subset of the sample. Furthermore, vascular risk was not a prominent determinant of these effects. These findings suggest that the overall blood supply to the brain is an important indicator of white-matter health in the normal range of variations amongst adults, and that the decline in CBF with advancing age may potentially exacerbate deterioration of the connective anatomy of the brain.
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DOI：
10.1097/00004647-200209000-00002
发表时间：
2002-09-01
影响因子：
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通讯作者：
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