Natural medicine delivery from biomedical devices to treat bone disorders: A review.
Natural medicine delivery from biomedical devices to treat bone disorders: A review.
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DOI：
10.1016/j.actbio.2021.02.034
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发表时间：
2021-05
影响因子：
9.7
通讯作者：
Banerjee D
中科院分区：
文献类型：
--
作者：
Bose S;Sarkar N;Banerjee D
随着预期寿命的增加和人口老龄化，骨科缺陷和骨移植手术在全球范围内的流行率越来越高。迄今为止的研究已经推进了对骨生物学和缺损修复机制的理解，导致合成骨替代物的开发取得了显着成功。然而，对功能化骨移植物的追求促使研究人员找到一种可行的替代方法，可以调节细胞活性，支持骨再生和愈合过程，而不会引起严重的副作用。最近，研究人员在骨支架中引入了天然药物化合物（NMCs），使其能够以理想的速率释放，保持持续释放，允许组织长入足够的时间，并引导骨再生过程，最大限度地降低组织毒性风险。据世卫组织称，过去二十年来，NMCs在西方国家越来越受欢迎，全球80%的人口正在使用。与合成药物相比，NMCs具有更宽的安全窗口范围，因此适合用于骨再生的长期局部递送。关于骨移植物与天然药物结合的文献很少，这些文献提供了关于NMCs、其毒性限制以及在骨组织工程中的特定应用的详细科学证据，这可以指导研究人员开发用于各种骨疾病的功能化植入物。本文将讨论从骨移植物中递送NMC的新趋势，包括3D打印结构和表面修饰的植入物，突出NMCs对骨健康的意义和潜力，指导未来发展理想的骨组织工程支架的道路。
With an increasing life expectancy and aging population, orthopedic defects and bone graft surgeries are increasing in global prevalence. Research to date has advanced the understanding of bone biology and defect repair mechanism, leading to a marked success in the development of synthetic bone substitutes. Yet, the quest for functionalized bone grafts prompted the researchers to find a viable alternative that regulates cellular activity and supports bone regeneration and healing process without causing serious side-effects. Recently, researchers have introduced natural medicinal compounds (NMCs) in bone scaffold that enables them to release at a desirable rate, maintains a sustained release allowing sufficient time for tissue in-growth, and guides bone regeneration process with minimized risk of tissue toxicity. According to WHO, NMCs are gaining popularity in western countries for the last two decades and are being used by 80% of the population worldwide. Compared to synthetic drugs, NMCs have a broader range of safety window and thus suitable for prolonged localized delivery for bone regeneration. There is limited literature focusing on the integration of bone grafts and natural medicines that provides detailed scientific evidences on NMCs, their toxic limits and particular application in bone tissue engineering, which could guide the researchers to develop functionalized implants for various bone disorders. This review will discuss the emerging trend of NMC delivery from bone grafts, including 3D-printed structures and surface-modified implants, highlighting the significance and potential of NMCs for bone health, guiding future paths toward the development of an ideal bone tissue engineering scaffold.
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