Spatial Coregistration of Functional Near-Infrared Spectroscopy to Brain MRI.
Spatial Coregistration of Functional Near-Infrared Spectroscopy to Brain MRI.
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DOI：
10.1111/jon.12432
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Holtzer R
中科院分区：
文献类型：
--
作者：
Chen M;Blumen HM;Izzetoglu M;Holtzer R
传统的神经成像技术限制了运动，使得研究需要口腔、上肢或下肢运动执行的过程变得困难。功能性近红外光谱（fNIRS）是一种光学神经成像模式，可测量脑氧合并允许数据采集期间的运动。然而，fNIRS的一个关键限制是缺乏将定量fNIRS测量与结构图像（如MRI）共配准的标准方法。此外，fNIRS-MRI联合登记研究尚未在老年人中报告。从30名非痴呆老年人中获得fNIRS和结构MRI。16个fNIRS通道，评估血流动力学变化的前额叶皮层（PFC;在各种年龄相关的过程中至关重要的领域）共同注册的结构MRI。维生素E胶囊用于标记头皮上fNIRS检测器和光源的位置。我们使用气球膨胀算法将头皮上的fNIRS通道位置投影到底层皮质表面。我们提供的16个fNIRS通道在PFC的皮质表面上的MNI和Talairach空间的坐标，具有最小的变化，这是在我们的fNIRS系统的空间分辨率。我们的研究为未来研究中的独立fNIRS数据提供了有用的空间信息，特别是与年龄相关过程的研究。
Traditional neuroimaging techniques restrict movement and make it difficult to study the processes that require oral, upper limb, or lower limb motor execution. Functional Near-Infrared Spectroscopy (fNIRS) is an optical neuroimaging modality that measures brain oxygenation and permits movement during data acquisition. A key limitation of fNIRS, however, is the lack of a standard method to co-register quantitative fNIRS measurements to structural images such as MRI. Additionally, fNIRS-MRI co-registration studies have not been reported in older adults. fNIRS and structural MRI were acquired from 30 non-demented older adults. Sixteen fNIRS channels that assess hemodynamic changes in the prefrontal cortex (PFC; an area crucial in various age-related processes) were co-registered to structural MRI. Vitamin E capsules were used to mark the locations of fNIRS detectors and light sources on the scalp. We used the balloon-inflation algorithm to project fNIRS channel locations on the scalp to underlying cortical surface. We provide coordinates for the 16 fNIRS channels in the PFC on the cortical surface in both MNI and Talairach spaces, with minimal variability that is within the spatial resolution of our fNIRS system. Our study provides useful spatial information for standalone fNIRS data in future studies, particularly investigations in age-related processes.
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