The Potential of Lung Epithelium Specific Proteins as Biomarkers for COVID-19-Associated Lung Injury.
The Potential of Lung Epithelium Specific Proteins as Biomarkers for COVID-19-Associated Lung Injury.
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DOI：
10.3390/diagnostics11091643
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发表时间：
2021-09-08
期刊：
影响因子：
--
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Almuntashiri S;James C;Wang X;Siddiqui B;Zhang D
严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 感染首先在中国武汉报告，并于 2020 年 3 月 20 日被世界卫生组织 (WHO) 宣布为大流行。呼吸系统是受 COVID-19 影响的主要器官系统。大量研究发现 COVID-19 患者存在肺部异常，包括呼吸短促、呼吸衰竭和急性呼吸窘迫综合征。鉴定易于在血清中测量的肺部特异性生物标志物对于临床医生和患有此类疾病的患者来说都是有价值的。本综述重点关注肺蛋白及其作为 COVID-19 相关肺损伤生物标志物的潜力，包括 Krebs von den Lungen-6 (KL-6)、表面活性蛋白（SP-A、SP-B、SP-C、SP-D）和 Clara 细胞分泌蛋白 (CC16)。目前的研究结果表明，上述肺蛋白可能反映肺部表现的严重程度，并可作为 COVID-19 相关肺损伤的潜在生物标志物。
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection was first reported in Wuhan, China, and was declared a pandemic by the World Health Organization (WHO) on 20 March 2020. The respiratory system is the major organ system affected by COVID-19. Numerous studies have found lung abnormalities in patients with COVID-19, including shortness of breath, respiratory failure, and acute respiratory distress syndrome. The identification of lung-specific biomarkers that are easily measurable in serum would be valuable for both clinicians and patients with such conditions. This review is focused on the pneumoproteins and their potential to serve as biomarkers for COVID-19-associated lung injury, including Krebs von den Lungen-6 (KL-6), surfactant proteins (SP-A, SP-B, SP-C, SP-D), and Clara cell secretory protein (CC16). The current findings indicate the aforementioned pneumoproteins may reflect the severity of pulmonary manifestations and could serve as potential biomarkers in COVID-19-related lung injury.
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