Aortic dissection simulation models for clinical support: fluid-structure interaction vs. rigid wall models.
Aortic dissection simulation models for clinical support: fluid-structure interaction vs. rigid wall models.
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DOI：
10.1186/s12938-015-0032-6
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发表时间：
2015-04-15
影响因子：
3.9
通讯作者：
Díaz-Zuccarini V
中科院分区：
文献类型：
--
作者：
Alimohammadi M;Sherwood JM;Karimpour M;Agu O;Balabani S;Díaz-Zuccarini V
主动脉夹层(AD)的治疗和预后经常是具有挑战性的，个性化计算模型的使用正在被探索作为一种改善临床结果的工具。在这样的模拟中包括血管壁运动可以提供更真实和潜在的准确结果，但需要大量的额外计算资源和专业知识。以临床翻译为最终目标，在复杂性、速度和准确性之间进行权衡是不可避免的。本研究通过对一个样本病例进行流体-结构相互作用(FSI)模拟，探讨在AD的情况下，模拟室壁运动是否值得额外的费用。从计算机断层扫描图像中提取特定于患者的解剖细节以提供流体区域，由此推断出血管壁。采用耦合的Windkesel边界条件和超弹性壁面特性，进行了双向流固耦合数值模拟。血液模型采用Carreau-Yasuda粘度模型，湍流模型采用切应力输运模型。为了比较的目的，进行了没有壁面运动(刚性墙)的模拟。就内膜瓣运动和真实管腔的收缩而言，血管壁的移位与影像研究的报告相当。对FSI模型中假腔近端和远端的血流动力学分析表明，由血管壁的扩张和收缩引起的复杂的流动结构。这些流动模式导致了对壁面剪应力的显著不同的预测，特别是其振荡分量，而刚性壁面模型没有捕捉到这一点。通过与成像数据的比较，本研究结果表明，本文所采用的流固耦合方法适用于主动脉夹层的模拟。壁面高切应力区域不会因壁面运动而明显改变，但某些壁面切应力较低且振荡的区域可能是疾病进展的关键，只有在FSI模拟中才能确定。我们的结论是，如果要将患者定制的主动脉夹层模拟作为介入计划工具，那么模拟室壁运动所需的额外复杂性、专业知识和计算费用确实是合理的。
The management and prognosis of aortic dissection (AD) is often challenging and the use of personalised computational models is being explored as a tool to improve clinical outcome. Including vessel wall motion in such simulations can provide more realistic and potentially accurate results, but requires significant additional computational resources, as well as expertise. With clinical translation as the final aim, trade-offs between complexity, speed and accuracy are inevitable. The present study explores whether modelling wall motion is worth the additional expense in the case of AD, by carrying out fluid-structure interaction (FSI) simulations based on a sample patient case. Patient-specific anatomical details were extracted from computed tomography images to provide the fluid domain, from which the vessel wall was extrapolated. Two-way fluid-structure interaction simulations were performed, with coupled Windkessel boundary conditions and hyperelastic wall properties. The blood was modelled using the Carreau-Yasuda viscosity model and turbulence was accounted for via a shear stress transport model. A simulation without wall motion (rigid wall) was carried out for comparison purposes. The displacement of the vessel wall was comparable to reports from imaging studies in terms of intimal flap motion and contraction of the true lumen. Analysis of the haemodynamics around the proximal and distal false lumen in the FSI model showed complex flow structures caused by the expansion and contraction of the vessel wall. These flow patterns led to significantly different predictions of wall shear stress, particularly its oscillatory component, which were not captured by the rigid wall model. Through comparison with imaging data, the results of the present study indicate that the fluid-structure interaction methodology employed herein is appropriate for simulations of aortic dissection. Regions of high wall shear stress were not significantly altered by the wall motion, however, certain collocated regions of low and oscillatory wall shear stress which may be critical for disease progression were only identified in the FSI simulation. We conclude that, if patient-tailored simulations of aortic dissection are to be used as an interventional planning tool, then the additional complexity, expertise and computational expense required to model wall motion is indeed justified.
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影响因子：
0.9
作者：
Karmonik, Christof;Bismuth, Jean;Lumsden, Alan B.
通讯作者：
Lumsden, Alan B.
影响因子：
2.4
作者：
Brown, Alistair G.;Shi, Yubing;Hose, D. Rodney
通讯作者：
Hose, D. Rodney
影响因子：
4.3
作者：
Karmonik, Christof;Duran, Cassidy;Bismuth, Jean
通讯作者：
Bismuth, Jean
DOI：
10.5301/ijao.5000310
发表时间：
2014-10-01
期刊：
The International journal of artificial organs
影响因子：
--
作者：
Alimohammadi, Mona;Bhattacharya-Ghosh, Benjamin;Diaz-Zuccarini, Vanessa
通讯作者：
Diaz-Zuccarini, Vanessa
影响因子：
2.4
作者：
Khanafer, Khalil;Berguer, Ramon
通讯作者：
Berguer, Ramon