Study on association of working hours and occupational physical activity with the occurrence of coronary heart disease in a Chinese population.
Study on association of working hours and occupational physical activity with the occurrence of coronary heart disease in a Chinese population.
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中国人群工作时间、职业体力活动与冠心病发生的相关性研究
DOI：
10.1371/journal.pone.0185598
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Wang LS
中科院分区：
文献类型：
--
作者：
Ma Y;Wang YJ;Chen BR;Shi HJ;Wang H;Khurwolah MR;Li YF;Xie ZY;Yang Y;Wang LS
目的探讨中国人群工作时间和职业体力活动（OPA）与冠心病（CHD）发生的关系。方法于2015年12月至2016年10月在南京医科大学第一附属医院开展研究，共纳入595名参与者，年龄在24 ~ 65岁之间，有冠心病和无冠心病患者分别为354例和241例。通过面对面问卷收集参与者特征，并进行logistic回归分析，探讨工作时间和OPA与冠心病发生的关系。结果与非就业人群相比，长时间工作（尤其是≥55小时/周）对冠心病的发生有促进作用（多因素调整后优势比[OR] = 2.213, 95%可信区间[CI]: 1.125, 4.355, P = 0.021）。随着工作时间的延长，冠心病风险增加（剂量-反应趋势P = 0.022）。同时，即使在调整了闲暇时间的体力活动后，工作中的久坐行为对冠心病风险也有不利影响（调整后OR = 2.794, 95%CI: 1.526, 5.115, P = 0.001）， OPA与冠心病之间也存在线性关系（趋势P = 0.005）。结论：长时间工作和久坐行为与冠心病的高风险相关。此外，在久坐不动的职业中，长时间的工作增加了冠心病的风险，这与业余时间的体育活动无关。
Objective To explore the association of working hours and occupational physical activity (OPA) with the occurrence of coronary heart disease (CHD) in a Chinese population. Methods A total of 595 participants (354 and 241 patients with and without CHD, respectively) aged between 24 and 65 were enrolled in our study, which was conducted at the First Affiliated Hospital of Nanjing Medical University between December 2015 and October 2016. Participant characteristics were collected from face-to-face questionnaires, and logistic regression analysis was conducted to examine the association of working hours and OPA with the occurrence of CHD. Results Compared with non-employed people, long working hours (especially ≥55 hours/week) contributed to the occurrence of CHD (adjusted odds ratio[OR] = 2.213, 95% confidence interval [CI]: 1.125, 4.355, P = 0.021) after multivariate adjustment in the Chinese population. With the extension of worktime, the CHD risk increased (P for the dose-response trend = 0.022). Meanwhile, even after adjusting for engagement in physical activity during leisure time, sedentary behavior at work had an adverse effect on CHD risk (adjusted OR = 2.794, 95%CI: 1.526, 5.115, P = 0.001), and a linear relationship was also found between OPA and CHD (P for the trend = 0.005). Conclusions Long working hours and sedentary behavior at work are associated with a high risk of CHD. In addition, prolonged working hours in sedentary occupations increases the risk of CHD, independent of engagement in leisure time physical activity.
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