Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study.
Protein, iron, and meat consumption and risk for rheumatoid arthritis: a prospective cohort study.
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DOI：
10.1186/ar2123
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发表时间：
2007
影响因子：
4.9
通讯作者：
Karlson EW
中科院分区：
文献类型：
--
作者：
Benito-Garcia E;Feskanich D;Hu FB;Mandl LA;Karlson EW
最近的一项前瞻性研究表明，红肉和总蛋白质的摄入量增加与炎症性多关节炎的风险增加有关。因此，我们前瞻性地研究了饮食（特别是蛋白质、铁和相应的食物来源）与82,063名护士健康研究中的女性类风湿性关节炎（RA）发病率之间的关系。从1980年至2002年，546例RA事件被确诊的结缔组织疾病筛查问卷和医疗记录审查的美国风湿病学会标准的RA。在1980年的基线和随访期间的五个额外的时间饮食进行了评估。我们进行了考克斯比例风险分析，计算与蛋白质（总，动物和蔬菜）和铁（总，膳食，补充剂和血红素铁）及其主要食物来源的摄入量相关的RA率比，调整年龄，吸烟，体重指数和生殖因素。多变量模型显示，RA与任何蛋白质或铁摄入量之间均无相关性。在最高和最低五分位摄入量的比较中，总蛋白质的率比为1.17（95%置信区间0.89-1.54;趋势P = 0.11），总铁的率比为1.04（95%置信区间0.77-1.41;趋势P = 0.82）。红肉、家禽和鱼也与RA风险无关。我们无法确认在这个庞大的女性队列中蛋白质或肉类与RA风险之间存在关联。在该队列中，铁也与RA无关。
A recent prospective study showed that higher consumption of red meat and total protein was associated with increased risk for inflammatory polyarthritis. We therefore prospectively examined the relationship between diet (in particular, protein, iron, and corresponding food sources) and incident rheumatoid arthritis (RA) among 82,063 women in the Nurses' Health Study. From 1980 to 2002, 546 incident cases of RA were confirmed by a connective tissue disease screening questionnaire and medical record review for American College of Rheumatology criteria for RA. Diet was assessed at baseline in 1980 and five additional times during follow up. We conducted Cox proportional hazards analyses to calculate the rate ratio of RA associated with intakes of protein (total, animal, and vegetable) and iron (total, dietary, from supplements, and heme iron) and their primary food sources, adjusting for age, smoking, body mass index, and reproductive factors. The multivariate models revealed no association between RA and any measure of protein or iron intake. In comparisons of highest with lowest quintiles of intake, the rate ratio for total protein was 1.17 (95% confidence interval 0.89–1.54; P for trend = 0.11) and for total iron it was 1.04 (95% confidence interval 0.77–1.41; P for trend = 0.82). Red meat, poultry, and fish were also not associated with RA risk. We were unable to confirm that there is an association between protein or meat and risk for RA in this large female cohort. Iron was also not associated with RA in this cohort.
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影响因子：
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作者：
Pattison, DJ;Symmons, DPM;Silman, AJ
通讯作者：
Silman, AJ
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NEPOM, GT;BYERS, P;NEPOM, BS
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NEPOM, BS
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Bingham, S
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KJELDSENKRAGH, J;HAUGEN, M;FORRE, O
通讯作者：
FORRE, O
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作者：
Symmons, DPM;Bankhead, CR;Silman, AJ
通讯作者：
Silman, AJ