Hydroxylation decoration patterns of flavonoids in horticultural crops: chemistry, bioactivity and biosynthesis.
Hydroxylation decoration patterns of flavonoids in horticultural crops: chemistry, bioactivity and biosynthesis.
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园艺作物中黄酮类化合物的羟基化修饰模式：化学、生物活性和生物合成
DOI：
10.1093/hr/uhab068
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发表时间：
2022-01-20
影响因子：
8.7
通讯作者：
Chen K
中科院分区：
文献类型：
--
作者：
Liu Y;Qian J;Li J;Xing M;Grierson D;Sun C;Xu C;Li X;Chen K
黄酮类化合物是最普遍的多酚化合物，并且是园艺作物如水果、蔬菜和茶中存在的重要膳食成分。天然黄酮类化合物是重要的质量性状，如食品颜色和有益的膳食抗氧化剂，许多研究表明，摄入黄酮类化合物可以降低各种非传染性疾病的发病率。对迄今报道的数千种黄酮类化合物的分析表明，不同的羟基化修饰会影响它们的化学性质和营养价值。这些不同的黄酮类化合物可以根据B、C和A环上不同的羟基化模式进行分类，多结构活性分析表明，在特定位置的羟基化修饰显著增强了它们的生物活性。本文重点介绍了几种不同类型的羟化酶催化黄酮类化合物羟化的最新知识。黄酮类化合物3′-羟化酶（F3′H）和黄酮类化合物3′5′-羟化酶（F3′5′H）是黄酮类化合物B环羟化的重要酶。黄烷酮3-羟化酶（F3 H）是C环羟基化的关键酶，而黄酮6-羟化酶（F6 H）和黄酮8-羟化酶（F8 H）是A环羟基化的关键酶。类黄酮生物合成途径中的这些关键羟化酶是未来植物生物工程和具有高营养重要性的指定羟化模式的类黄酮的大规模生产的有希望的目标。此外，环上关键位置的羟基化可能有助于使黄酮类化合物准备好降解，而黄酮类化合物的分解代谢周转可能为新的研究路线打开大门。
Flavonoids are the most widespread polyphenolic compounds and are important dietary constituents present in horticultural crops such as fruits, vegetables, and tea. Natural flavonoids are responsible for important quality traits, such as food colors and beneficial dietary antioxidants, and numerous investigations have shown that intake of flavonoids can reduce the incidence of various non-communicable diseases. Analysis of the thousands of flavonoids reported so far has shown that different hydroxylation modifications affect their chemical properties and nutritional values. These diverse flavonoids can be classified based on different hydroxylation patterns in the B, C, and A rings and multiple structure–activity analyses have shown that hydroxylation decoration at specific positions markedly enhances their bioactivities. This review focuses on current knowledge concerning hydroxylation of flavonoids catalyzed by several different types of hydroxylase enzymes. Flavonoid 3′-hydroxylase (F3′H) and flavonoid 3′5′-hydroxylase (F3′5′H) are important enzymes for the hydroxylation of the B ring of flavonoids. Flavanone 3-hydroxylase (F3H) is key for the hydroxylation of the C ring, while flavone 6-hydroxylase (F6H) and flavone 8-hydroxylase (F8H) are key enzymes for hydroxylation of the A ring. These key hydroxylases in the flavonoid biosynthesis pathway are promising targets for the future bioengineering of plants and mass production of flavonoids with designated hydroxylation patterns of high nutritional importance. In addition, hydroxylation in key places on the ring may help render flavonoids ready for degradation, and the catabolic turnover of flavonoids may open the door for new lines of inquiry.
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DOI：
10.1111/j.1432-1033.1986.tb09616.x
发表时间：
1986-05-02
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
BRITSCH, L;GRISEBACH, H
通讯作者：
GRISEBACH, H
影响因子：
8.4
作者：
Appelhagen I;Wulff-Vester AK;Wendell M;Hvoslef-Eide AK;Russell J;Oertel A;Martens S;Mock HP;Martin C;Matros A
通讯作者：
Matros A
DOI：
10.3390/molecules25245850
发表时间：
2020-12-11
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Chobot V;Hadacek F;Bachmann G;Weckwerth W;Kubicova L
通讯作者：
Kubicova L
影响因子：
7.4
作者：
Bogs, J;Ebadi, A;Robinson, SP
通讯作者：
Robinson, SP
影响因子：
7.4
作者：
Du, Yegang;Chu, Hung;Lo, Clive
通讯作者：
Lo, Clive