Development of Inhalable Chitosan-Coated Oxymatrine Liposomes to Alleviate RSV-Infected Mice.
Development of Inhalable Chitosan-Coated Oxymatrine Liposomes to Alleviate RSV-Infected Mice.
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开发可吸入的壳聚糖包被的氧化苦参碱脂质体以减轻 RSV 感染小鼠的症状
DOI：
10.3390/ijms232415909
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发表时间：
2022-12-14
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
Human respiratory syncytial virus (RSV) infection is the most important cause of acute lower respiratory tract infection in infants, neonates, and young children, even leading to hyperinflation and atelectasis. Oxymatrine (OMT), originating from natural herbs, possessed potential antivirus activity against influenza A virus, Coxsackie B3 virus, and RSV, whereas the absence of an in vivo study indicated the difficulties in overcoming the physiological obstacles. Since RSV basically replicated in lung tissue, in this study, we fabricated and characterized a chitosan (CS)-coated liposome with OMT loaded for the treatment of lethal RSV infection via inhalation. The results uncovered that OMT, as a hydrophilic drug, was liable to diffuse in the mucus layer and penetrate through the gas–blood barrier to enter systemic circulation quickly, which might restrict its inhibitory effect on RSV replication. The CS-coated liposome enhanced the distribution and retention of OMT in lung tissue without restriction from mucus, which contributed to the improved alleviative effect of OMT on lethal RSV-infected mice. Overall, this study provides a novel inhalation therapy for RSV infection, and the CS-coated liposome might be a potential inhalable nanocarrier for hydrophilic drugs to prevent pulmonary infections.
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影响因子：
5.7
作者：
Boroumand H;Badie F;Mazaheri S;Seyedi ZS;Nahand JS;Nejati M;Baghi HB;Abbasi-Kolli M;Badehnoosh B;Ghandali M;Hamblin MR;Mirzaei H
通讯作者：
Mirzaei H
影响因子：
5
作者：
De Leo V;Milano F;Agostiano A;Catucci L
通讯作者：
Catucci L
DOI：
10.3390/molecules27113610
发表时间：
2022-06-04
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
通讯作者：
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CFH 肽修饰的脂质体氧化苦参碱通过上皮-间质转化逆转灭活肝细胞癌的癌症相关成纤维细胞
影响因子：
10.2
作者：
Guo J;Zeng H;Shi X;Han T;Liu Y;Liu Y;Liu C;Qu D;Chen Y
通讯作者：
Chen Y
影响因子：
5.4
作者：
Ma, SC;Du, J;Lee, SF
通讯作者：
Lee, SF