Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles.
Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles.
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DOI：
10.3390/polym13071027
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发表时间：
2021-03-26
期刊：
影响因子：
5
通讯作者：
Catucci L
中科院分区：
文献类型：
--
作者：
De Leo V;Milano F;Agostiano A;Catucci L
脂质体是一种被广泛应用于药物输送领域的纳米仿生载体。脂质体的结构多样性已被用于药物和生物活性分子的局部或系统递送的各种载体的开发，有可能提高它们的生物利用度和稳定性，并调节和指导它们的释放，同时限制副作用。然而，第一代囊泡受到一些限制，包括物理不稳定，体内循环寿命短，有效载荷减少，释放特性不受控制，靶向能力低。因此，脂质体制备技术很快利用了使用天然和合成聚合物改善囊泡性能的可能性。聚合物可以很容易地在较宽的相对分子质量范围和低分散度范围内以可控的方式合成。它们的性质是广泛可调的，因此可以克服脂类典型的低化学通用性。此外，根据聚合物的结构，聚合物可用于在脂质体表面创建简单的覆盖层或插入磷脂双层以产生真正的杂化结构。本综述阐述了聚合物/脂质体药物传递组装领域中实施的主要策略，并在不忽略基本概念的情况下查看了最新的出版物，以便于读者简单而完整地理解。
Liposomes are consolidated and attractive biomimetic nanocarriers widely used in the field of drug delivery. The structural versatility of liposomes has been exploited for the development of various carriers for the topical or systemic delivery of drugs and bioactive molecules, with the possibility of increasing their bioavailability and stability, and modulating and directing their release, while limiting the side effects at the same time. Nevertheless, first-generation vesicles suffer from some limitations including physical instability, short in vivo circulation lifetime, reduced payload, uncontrolled release properties, and low targeting abilities. Therefore, liposome preparation technology soon took advantage of the possibility of improving vesicle performance using both natural and synthetic polymers. Polymers can easily be synthesized in a controlled manner over a wide range of molecular weights and in a low dispersity range. Their properties are widely tunable and therefore allow the low chemical versatility typical of lipids to be overcome. Moreover, depending on their structure, polymers can be used to create a simple covering on the liposome surface or to intercalate in the phospholipid bilayer to give rise to real hybrid structures. This review illustrates the main strategies implemented in the field of polymer/liposome assembly for drug delivery, with a look at the most recent publications without neglecting basic concepts for a simple and complete understanding by the reader.
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影响因子：
5.4
作者：
Bulbake U;Doppalapudi S;Kommineni N;Khan W
通讯作者：
Khan W
影响因子：
8
作者：
Abdellatif, Menna M.;Khalil, Islam A.;Al-Mokaddem, Asmaa K.
通讯作者：
Al-Mokaddem, Asmaa K.
DOI：
10.1016/0304-4165(86)90197-2
发表时间：
1986-12-10
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
CONNOR, J;NORLEY, N;HUANG, L
通讯作者：
HUANG, L
影响因子：
5.6
作者：
Chen, Yufeng;Xia, Guobin;Zhang, Ying
通讯作者：
Zhang, Ying
影响因子：
5.8
作者：
Adamczak, Malgorzata I.;Hagesaether, Ellen;Hiorth, Marianne
通讯作者：
Hiorth, Marianne