Bullous drug eruption after second dose of mRNA-1273 (Moderna) COVID-19 vaccine: Case report.
Bullous drug eruption after second dose of mRNA-1273 (Moderna) COVID-19 vaccine: Case report.
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第二剂 mRNA-1273 (Moderna) COVID-19 疫苗后出现大疱性药疹：病例报告。
DOI：
10.1016/j.jiph.2021.06.021
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发表时间：
2021-10
影响因子：
6.7
通讯作者：
Mathew A
中科院分区：
文献类型：
--
作者：
Kong J;Cuevas-Castillo F;Nassar M;Lei CM;Idrees Z;Fix WC;Halverstam C;Mir A;Elbendary A;Mathew A
2020年12月，Moderna发布了mRNA-1273疫苗。最常见的副作用是头痛、肌肉疼痛、发红、肿胀和注射部位压痛。此外，还有皮肤病学不良事件，如超敏反应。虽然罕见，但接种疫苗后已描述了各种大疱性出疹。据报道，大疱性类天疱疮最常发生在接种流感和白喉-破伤风-百日咳疫苗后。据我们所知，目前还没有关于mRNA疫苗引起大疱性药疹的报道。一名66岁的肥胖圭亚那男性在接受商业COVID-19 mRNA疫苗后出现大疱性皮疹。他顺利地接受了第一剂。然而，在接受第二次给药后24小时内，患者出现发热、肌痛和不适，并伴有躯干、手臂和腿部疼痛性起泡皮疹。他的发热和肌痛在24小时后改善，但他的疼痛性皮疹没有改善，在最初症状出现5天后，他到医院就诊。在检查时，他的躯干、手臂和大腿上有许多紫色的、边界不清的斑块，其中许多斑块内有大的松弛性大疱，臀部、后肩和阴囊上的一些区域被侵蚀。下肢肌肉压痛、僵硬和保留力量的检查也有意义。皮肤活检显示表皮坏死和稀疏的血管周围皮炎，涉及史蒂文斯-约翰逊综合征或多形红斑。然而，在没有粘膜受累或靶样病变的情况下，诊断为广泛的大疱性固定性药疹。该病例说明了大疱出疹是由于接受Moderna疫苗接种所致。
In December 2020, Moderna released the mRNA-1273 vaccine. The most common side effects are headache, muscle pain, redness, swelling, and tenderness at the injection site. In addition, there have been dermatological adverse events, such as hypersensitivity reactions. Although rare, various bullous eruptions have been described following vaccination. Bullous pemphigoid has been reported to occur most often after receipt of influenza and the diphtheria-tetanus-pertussis vaccine. To the best of our knowledge, there have been no reports of bullous drug eruptions resulting from mRNA vaccines. A 66-years-old obese Guyanese male presented with a bullous rash following receipt of a commercial COVID-19 mRNA vaccine. He received the first dose uneventfully. However, within 24 h of receiving the second dose, he developed fever, myalgias, and malaise accompanied by a painful blistering rash of his torso, arms, and legs. His fever and myalgias improved after 24 h, but his painful rash did not, and five days after the initial symptoms, he presented to the hospital. There were many violaceous, poorly demarcated patches on his trunk, arms, and thighs on examination, many of which had large flaccid bullae within, and a few areas on his buttocks, posterior shoulder, and scrotum were eroded. The exam was also significant for lower extremity muscle tenderness, stiffness with preserved strength. A skin biopsy showed epidermal necrosis and sparse perivascular dermatitis concerning Stevens-Johnson syndrome or erythema multiforme. However, in the absence of mucous membrane involvement or targetoid lesions, the diagnosis of an extensive bullous fixed drug eruption was made. This case illustrates that the bullae eruption occurred as a result of receiving the Moderna vaccination.
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影响因子：
6.1
作者：
Young, Sarah;Fernandez, Anthony P
通讯作者：
Fernandez, Anthony P
DOI：
10.1007/978-1-4471-6729-7_24
发表时间：
2015-05-15
期刊：
Cutaneous Drug Eruptions
影响因子：
--
作者：
Klimas N;Quintanilla-Dieck J;Vandergriff T
通讯作者：
Vandergriff T
DOI：
10.1056/nejmoa2028436
发表时间：
2020-12-17
期刊：
The New England journal of medicine
影响因子：
--
作者：
Anderson EJ;Rouphael NG;Widge AT;Jackson LA;Roberts PC;Makhene M;Chappell JD;Denison MR;Stevens LJ;Pruijssers AJ;McDermott AB;Flach B;Lin BC;Doria-Rose NA;O'Dell S;Schmidt SD;Corbett KS;Swanson PA 2nd;Padilla M;Neuzil KM;Bennett H;Leav B;Makowski M;Albert J;Cross K;Edara VV;Floyd K;Suthar MS;Martinez DR;Baric R;Buchanan W;Luke CJ;Phadke VK;Rostad CA;Ledgerwood JE;Graham BS;Beigel JH;mRNA-1273 Study Group
通讯作者：
mRNA-1273 Study Group
影响因子：
5.5
作者：
Su, John R.;Haber, Penina;Cano, Maria, V
通讯作者：
Cano, Maria, V
影响因子：
158.5
作者：
Jackson, L. A.;Anderson, E. J.;Beigel, J. H.
通讯作者：
Beigel, J. H.