Transcutaneous electrical acupoint stimulation for children with attention-deficit/hyperactivity disorder: a randomized clinical trial.
Transcutaneous electrical acupoint stimulation for children with attention-deficit/hyperactivity disorder: a randomized clinical trial.
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DOI：
10.1038/s41398-022-01914-0
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发表时间：
2022-04-21
影响因子：
6.8
通讯作者：
Li, Yan
中科院分区：
文献类型：
--
作者：
Zhuo, Lixia;Zhao, Xiaoyan;Zhai, Yifang;Zhao, Boqiang;Tian, Lin;Zhang, Yannan;Wang, Xiaodan;Zhang, Tingyu;Gan, Xinyi;Yang, Cheng;Wang, Weigang;Gao, Wei;Wang, Qiang;Rohde, Luis Augusto;Zhang, Jie;Li, Yan
关于经皮电穴位刺激(TEA)对注意力缺陷/多动障碍(ADHD)儿童的影响，人们知之甚少。在这里，我们进行了一项为期4周的随机临床试验，其中6-12岁的 诊断为多动症的患者接受茶或假茶治疗。主要结果是在第4周进行研究者评定的临床总体印象改善评分。次要结果包括研究者评定的临床总体印象-疾病严重程度(CGI-S)评分、Conners父母/教师评定量表修订后的变化：简表(CPRS-R：S/CTRS-R：S)评分、进行/不进行任务表现以及基于功能性近红外光谱(FNIRS)的额叶皮质内氧合血红蛋白水平。在第4周，茶组33.3%的CGI-I评分较假手术组的7.7%有改善(P = 0.005)。茶组CGI-S评分(−0.87)较假茶组(−0.28)下降幅度更大(P = 0.003)。与假茶组(0.005 mm mm)相比，茶组前额叶皮质的平均脑氧合血红蛋白(0.099 mm mm)有更大的提高(P <； 0.001)。CPRS-R：S评分、CTRS-R：S评分、GO/NO-GO成绩在治疗后均无明显改善。与操作相关的不良事件在两组中都不常见，而且事件非常轻微。我们的结果显示，在4 周内，非侵入性TEA显著改善了ADHD儿童的一般症状并增加了前额叶皮质的血流量。还需要进一步的临床试验，以了解在更大的临床样本中的长期疗效。这项试验在ClinicalTrials.gov上注册(NCT 03917953)。
Little is known about the effects of transcutaneous electrical acupoint stimulation (TEAS) for children with attention-deficit/hyperactivity disorder (ADHD). Here, we carried out a 4 week randomized clinical trial in which patients aged 6–12 years old with an ADHD diagnosis received TEAS or sham TEAS. The primary outcome measure was the investigator-rated Clinical Global Impression-Improvement (CGI-I) score at week 4. Secondary outcomes included changes from baseline to week 4 in the investigator-rated Clinical Global Impression-Severity of Illness (CGI-S) score, the Conners’ Parent/Teacher Rating Scales-Revised: Short Form (CPRS-R: S/CTRS-R: S) score, go/no-go task performance, and functional near-infrared spectroscopy (fNIRS)-based oxygenated hemoglobin level within the prefrontal cortex. At week 4, the CGI-I score indicated improvement in 33.3% of the TEAS group compared with 7.7% of the sham group (P = 0.005). The TEAS group had a greater decrease in the mean CGI-S score (−0.87) than the sham TEAS group (−0.28) (P = 0.003). A greater enhancement in the mean cerebral oxygenated hemoglobin within the prefrontal cortex was found in the TEAS group (0.099 mM mm) compared with the sham TEAS group (0.005 mM mm) (P < 0.001). CPRS-R: S score, CTRS-R: S score, and go/no-go performance exhibited no significant improvement after TEAS treatment. The manipulation-associated adverse events were uncommon in both groups, and events were very mild. Our results show that noninvasive TEAS significantly improved general symptoms and increased prefrontal cortex blood flow within 4 weeks for children with ADHD. Further clinical trials are required to understand the long-term efficacy in a larger clinical sample. This trial was registered on ClinicalTrials.gov (NCT 03917953).
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