Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases.
Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases.
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强组胺扭转拉曼光谱可直接、快速、超灵敏地检测过敏性疾病
DOI：
10.1016/j.isci.2021.103384
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发表时间：
2021-11-19
期刊：
影响因子：
5.8
通讯作者：
Wu X
中科院分区：
文献类型：
--
作者：
Zhu H;Liu S;Guo Z;Yan K;Shen J;Zhang Z;Chen J;Guo Y;Liu L;Wu X
Allergic diseases are closely related to degranulation and release of histamine and difficult to diagnose because non-allergic diseases also exhibit the same clinical symptoms as allergy. Here, we report direct, rapid, and ultrasensitive detection of histamine using low-frequency molecular torsion Raman spectroscopy. We show that the low-frequency (<200 cm−1) Raman spectral intensities are stronger by one order of magnitude than those of the high-frequency Raman ones. Density functional theory calculation and nuclear magnetic resonance spectroscopy identify the strong spectral feature to be from torsions of carbon-carbon single bonds, which produce large variations of the polarizability densities in the imidazole ring and ethyl amino side chain. Using an omniphobic substrate and surface plasmonic effect of Au@SiO2 nanoparticles, the detection limit (signal-noise ratio >3) of histamine reaches 10−8 g/L in water and 10−6 g/L in serum. This scheme thus opens new lines of inquiry regarding the clinical diagnosis of allergic diseases. The low-frequency Raman intensity of histamine is stronger than the high-frequency ones The large Raman intensities arise from torsion vibrations of the C-C single bonds The detection limit of histamine reaches 10−8 g/L in water and 10−6 g/L in serum The whole detection testing only takes less than 20 min Biochemistry; Engineering; Surface sensing
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影响因子：
6.2
作者：
Gao, Fang;Grant, Edward;Lu, Xiaonan
通讯作者：
Lu, Xiaonan
影响因子：
4.6
作者：
Nakamura Y;Ishimaru K;Shibata S;Nakao A
通讯作者：
Nakao A
影响因子：
30.5
作者：
Lambrecht, Bart N.;Hammad, Hamida
通讯作者：
Hammad, Hamida
影响因子：
16.6
作者：
Chassin H;Geering B;Schukur L;Ausländer D;Lang B;Fussenegger M
通讯作者：
Fussenegger M
影响因子：
4.4
作者：
Papadopoulos NG;Agache I;Bavbek S;Bilo BM;Braido F;Cardona V;Custovic A;Demonchy J;Demoly P;Eigenmann P;Gayraud J;Grattan C;Heffler E;Hellings PW;Jutel M;Knol E;Lötvall J;Muraro A;Poulsen LK;Roberts G;Schmid-Grendelmeier P;Skevaki C;Triggiani M;Vanree R;Werfel T;Flood B;Palkonen S;Savli R;Allegri P;Annesi-Maesano I;Annunziato F;Antolin-Amerigo D;Apfelbacher C;Blanca M;Bogacka E;Bonadonna P;Bonini M;Boyman O;Brockow K;Burney P;Buters J;Butiene I;Calderon M;Cardell LO;Caubet JC;Celenk S;Cichocka-Jarosz E;Cingi C;Couto M;Dejong N;Del Giacco S;Douladiris N;Fassio F;Fauquert JL;Fernandez J;Rivas MF;Ferrer M;Flohr C;Gardner J;Genuneit J;Gevaert P;Groblewska A;Hamelmann E;Hoffmann HJ;Hoffmann-Sommergruber K;Hovhannisyan L;Hox V;Jahnsen FL;Kalayci O;Kalpaklioglu AF;Kleine-Tebbe J;Konstantinou G;Kurowski M;Lau S;Lauener R;Lauerma A;Logan K;Magnan A;Makowska J;Makrinioti H;Mangina P;Manole F;Mari A;Mazon A;Mills C;Mingomataj E;Niggemann B;Nilsson G;Ollert M;O'Mahony L;O'Neil S;Pala G;Papi A;Passalacqua G;Perkin M;Pfaar O;Pitsios C;Quirce S;Raap U;Raulf-Heimsoth M;Rhyner C;Robson-Ansley P;Alves RR;Roje Z;Rondon C;Rudzeviciene O;Ruëff F;Rukhadze M;Rumi G;Sackesen C;Santos AF;Santucci A;Scharf C;Schmidt-Weber C;Schnyder B;Schwarze J;Senna G;Sergejeva S;Seys S;Siracusa A;Skypala I;Sokolowska M;Spertini F;Spiewak R;Sprikkelman A;Sturm G;Swoboda I;Terreehorst I;Toskala E;Traidl-Hoffmann C;Venter C;Vlieg-Boerstra B;Whitacker P;Worm M;Xepapadaki P;Akdis CA
通讯作者：
Akdis CA