Small circular single stranded DNA viral genomes in unexplained cases of human encephalitis, diarrhea, and in untreated sewage.
Small circular single stranded DNA viral genomes in unexplained cases of human encephalitis, diarrhea, and in untreated sewage.
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DOI：
10.1016/j.virol.2015.03.011
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发表时间：
2015-08
期刊：
影响因子：
3.7
通讯作者：
Delwart, Eric
中科院分区：
文献类型：
--
作者：
Tung Gia Phan;Mori, Daisuke;Deng, Xutao;Rajindrajith, Shaman;Ranawaka, Udaya;Terry Fei Fan Ng;Bucardo-Rivera, Filemon;Orlandi, Patricia;Ahmed, Kamruddin;Delwart, Eric
具有小的环状rep编码ssDNA（CRESS-DNA）基因组的病毒可以感染从哺乳动物到真菌的广泛的真核生物。通过对斯里兰卡不明原因脑炎患者的脑脊液进行深度测序，检测了两种新型CRESS-DNA病毒的基因组，即环状病毒（CyCV-SL）和Gemycircularvirus（GemyCVSL）。201例不明原因脑炎患者脑脊液PCR检测CyCV-SL和GemyCV-SL DNA阳性率分别为1例和3例（1.5%）。对现有数据集的核苷酸相似性搜索揭示了来自尼加拉瓜和巴西的不明原因腹泻病例的粪便以及尼泊尔未经处理的污水中的相关基因组。本文报道的环状病毒和多环病毒的嗜性是否包括人类，或者它们的检测是否反映了人体内或人体上其他细胞来源的产生，仍有待确定。
Viruses with small circular rep-encoding ssDNA (CRESS-DNA) genomes can infect a wide range of eukaryotic organisms ranging from mammals to fungi. The genomes of two novel CRESS-DNA viruses, a cyclovirus (CyCV-SL) and gemycircularvirus (GemyCVSL) were detected by deep sequencing of the cerebrospinal fluids of Sri Lankan patients with unexplained encephalitis. One and three out of 201 CSF samples (1.5%) from unexplained encephalitis patients tested by PCR were CyCV-SL and GemyCV-SL DNA positive respectively. Nucleotide similarity searches of pre-existing datasets revealed related genomes in feces from unexplained cases of diarrhea from Nicaragua and Brazil and in untreated sewage from Nepal. Whether the tropism of the cycloviruses and gemycircularviruses reported here include humans or their detection reflects production from other cellular sources in or on the human body remains to be determined.
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影响因子：
11.8
作者：
Li L;McGraw S;Zhu K;Leutenegger CM;Marks SL;Kubiski S;Gaffney P;Dela Cruz FN Jr;Wang C;Delwart E;Pesavento PA
通讯作者：
Pesavento PA
影响因子：
3.8
作者：
Dayaram, Anisha;Potter, Kristen A.;Varsani, Arvind
通讯作者：
Varsani, Arvind
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影响因子：
3.8
作者：
Ge, Xingyi;Li, Jialu;Shi, Zhengli
通讯作者：
Shi, Zhengli
影响因子：
5
作者：
Dayaram, Anisha;Opong, Allen;Varsani, Arvind
通讯作者：
Varsani, Arvind
影响因子：
3.8
作者：
Garigliany, Mutien-Marie;Boerstler, Jessica;Cadar, Daniel
通讯作者：
Cadar, Daniel