Light-triggered theranostics based on photosensitizer-conjugated carbon dots for simultaneous enhanced-fluorescence imaging and photodynamic therapy.
Light-triggered theranostics based on photosensitizer-conjugated carbon dots for simultaneous enhanced-fluorescence imaging and photodynamic therapy.
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DOI：
10.1002/adma.201200650
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发表时间：
2012-09-25
影响因子：
29.4
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Huang, Peng;Lin, Jing;Wang, Xiansong;Wang, Zhe;Zhang, Chunlei;He, Meng;Wang, Kan;Chen, Feng;Li, Zhiming;Shen, Guangxia;Cui, Daxiang;Chen, Xiaoyuan
治疗诊断学结合了医学诊断学和治疗学，以实现综合方案的最佳疗效和安全性，是一门新兴的交叉学科，为实现个性化医疗的目标铺平了道路。[1]可活化的治疗诊断剂可以增强疾病破坏的选择性和特异性，具有高的局部细胞毒性和很少的附带损伤。[2]到目前为止，已经提出通过外部刺激如温度、pH、施加的磁场或电场、超声、光或酶促作用的可控活化作为触发递送系统。[3]在过去的十年中，光触发治疗诊断学，如光动力学，光热和光触发化学疗法由于化合物释放的高度特异性空间和时间控制的优势而受到越来越多的关注。[4]治疗诊断结构可以推进一种新的类别的临床解决方案，它具有早期识别的疾病，通过增强对比度在各种成像模式，然后通过定制的therapeutic guidance.Photodynamic therapy（PDT）是一个非凡的治疗诊断模式的一些恶性和非恶性疾病。[5]PDT的一般程序涉及全身、局部或局部施用称为光敏剂（PS）的无毒药物或染料，然后用适当波长和功率的光进行选择性照射。[2e在氧气存在下，PS可以将吸收的光子能量转移到周围的氧分子，产生包括单线态氧（SO）或自由基的活性氧物质（ROS），从而导致细胞死亡和组织破坏。同时，在光激活时，由于激发单重态PS弛豫回到基态，PS可以发射荧光。[1e]它所发出的荧光可用于疾病定位、光诊断和分子成像，被称为光敏剂荧光检测（PFD）。[4a因此，PFD和PDT的有机融合使得能够实现用于疾病检测的药物的在线成像、图像引导的药物递送和治疗、手术切除的引导以及治疗反应的监测。[八]《中国日报》
Theranostics, combining both medical diagnostics and therapeutics to achieve an optimizing efficacy and safety of comprehensive regime, is an emerging interdiscipline that is paving the avenue towards the goal of personalized medicine.[1] Activatable theranostic agents can enhance the selectivity and specificity for disease destruction with high localized cytotoxicity and little collateral damage.[2] So far, controllable activation by an external stimulus such as temperature, pH, applied magnetic or electrical field, ultrasound, light, or enzymatic action have been proposed as triggered delivery systems.[3] Over the past decade, light-triggered theranostics, such as photodynamic-, photothermal-and photo-triggered chemotherapy have received increased attention due to the advantage of highly specific spatial and temporal control of compound release.[4] The theranostic constructs could advance a novel category of clinical solution which possesses early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy.Photodynamic therapy (PDT) is an extraordinary theranostic modality for a number of malignant and nonmalignant diseases.[5] The general procedure of PDT involves the systemic, local, or topical administration of a non-toxic drug or dye known as a photosensitizer (PS) followed by selective illumination with appropriate wavelength and power of light.[2e, 6] In the presence of oxygen, PS can transfer the absorbed photon energy to surrounding oxygen molecules, generating reactive oxygen species (ROS) including singlet oxygen (SO) or free radicals and consequently causing cell death and tissue destruction. Meanwhile, upon light activation, PS can emit fluorescence due to the relaxation of the excited-singlet-state PS back to the ground state.[1e] The emitted fluorescence can be employed for locating diseases, photodiagnosis and molecular imaging, which is known as photosensitizer fluorescence detection (PFD).[4a, 7] Therefore, organic fusion of PFD and PDT enables online imaging of drug for the detection of disease, imageguided drug delivery and treatments, guidance of surgical resection, and monitoring of treatment response.[8]
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