Multicriteria optimization informed VMAT planning.
Multicriteria optimization informed VMAT planning.
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DOI：
10.1016/j.meddos.2013.10.001
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Gierga DP
中科院分区：
文献类型：
--
作者：
Chen H;Craft DL;Gierga DP
我们开发了一个患者特定的VMAT优化程序，使用DVH信息从多标准优化（MCO）的IMRT计划。本研究选择前列腺标准分割10例（42次fx），低分割10例（5次fx），头颈部5例（33次fx）。在RayStation治疗计划系统（临床版本2.5，RaySearch Laboratories，斯德哥尔摩，瑞典）上为每名患者生成使用20个和7个治疗射野的MCO-IMRT计划。将每例患者的20场MCO-IMRT计划的DVH结果用作参考DVH，并将MCO-IMRT计划的DVH结果的提取点值用作VMAT优化的目标和约束。进一步调整VMAT优化的目标和/或约束的权重，以生成与MCO-IMRT计划的参考DVH的最佳匹配。根据均匀性指数（HI）、PTV符合数（CN）和OAR保留，与MCO-IMRT计划进行比较，评价最终最佳VMAT计划质量。还评估了机架间距、弧数和输送时间对不同肿瘤部位的VMAT计划质量的影响。由此产生的VMAT计划质量基本上与20场-MCO-IMRT计划相匹配，但输送时间更短，MU更少。使用双弧改善了头颈部病例的VMAT计划质量，而前列腺病例则没有。对于头/颈病例和低分割前列腺病例，通过精细机架间距2改善了VMAT计划质量，但对于标准分割前列腺病例则没有改善。MCO通知的VMAT优化是一种有用且有价值的方式，以生成患者特定的最佳VMAT计划，尽管从MCO-IMRT的所得DVH中提取的目标和/或约束的权重的修改是必要的。
We developed a patient specific VMAT optimization procedure using DVH information from Multi-Criteria Optimization (MCO) of IMRT plans. 10 standard fractionation (42 fxs) prostate, 10 hypofractionation prostate patients (5 fxs) and 5 head/neck patients (33 fxs) were selected in this study. MCO-IMRT plans using 20 and 7 treatment fields were generated for each patient on the RayStation treatment planning system (clinical version 2.5, RaySearch Laboratories, Stockholm, Sweden). The resulting DVH of the 20field-MCO-IMRT plan for each patient was used as the reference DVH, and extracted point values of the resulting DVH of the MCO-IMRT plan were used as objectives and constraints for VMAT optimization. Weights of objectives and/or constraints of VMAT optimization were further tuned to generate the best match with the reference DVH of the MCO-IMRT plan. The final optimal VMAT plan quality was evaluated by comparison with MCO-IMRT plans based on homogeneity index (HI), Conformity number (CN) of PTV and OAR sparing. The influence of gantry spacing, arc number, and delivery time on VMAT plan quality for different tumor sites was also evaluated. The resulting VMAT plan quality essentially matched the 20field-MCO-IMRT plan but with a shorter delivery time and less MU. VMAT plan quality of head/neck cases improved using dual arcs while prostate cases did not. VMAT plan quality was improved by fine gantry spacing of 2 for the head/neck cases and the hypofractionation prostate cases but not for the standard fractionation prostate cases. MCO-informed VMAT optimization is a useful and valuable way to generate patient specific optimal VMAT plans though modification of the weights of objectives and/or constraints extracted from resulting DVH of MCO-IMRT is necessary.
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影响因子：
0.9
作者：
Sankaralingam M;Glegg M;Smith S;James A;Rizwanullah M
通讯作者：
Rizwanullah M
影响因子：
3.5
作者：
YU, CX
通讯作者：
YU, CX
影响因子：
3.5
作者：
Craft, David;Bortfeld, Thomas
通讯作者：
Bortfeld, Thomas
影响因子：
5.7
作者：
Cozzi, Luca;Dinshaw, Ketayun Ardeshir;Fogliata, Antonella
通讯作者：
Fogliata, Antonella
DOI：
10.1186/1748-717x-5-110
发表时间：
2010-11-22
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Alvarez-Moret J;Pohl F;Koelbl O;Dobler B
通讯作者：
Dobler B