Anthrax lethal and edema toxins in anthrax pathogenesis.

Anthrax lethal and edema toxins in anthrax pathogenesis.
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DOI:
10.1016/j.tim.2014.02.012
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发表时间:
2014-06
影响因子:
15.9
通讯作者:
Leppla, Stephen H.
Leppla, Stephen H.
中科院分区:
生物学1区
文献类型:
--
作者:
Liu, Shihui;Moayeri, Mahtab;Leppla, Stephen H.

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许多细菌性疾病引起的病理生理效应是由细菌释放的外毒素引起的。炭疽芽孢杆菌(Bacillus anthracis)是一种产芽孢细菌,它通过细菌感染和毒血症的结合引起炭疽病。炭疽杆菌会引起人类和动物的自然感染,自 2001 年美国炭疽袭击以来一直是生物恐怖主义的首要关注点。炭疽杆菌分泌的外毒素以CMG2为主要毒素受体,在整个疾病的发病过程中发挥重要作用。本综述重点关注炭疽毒素的活性及其在炭疽感染初期和晚期的作用。
The pathophysiological effects resulting from many bacterial diseases are caused by exotoxins released by the bacteria. Bacillus anthracis, a spore-forming bacterium, is such a pathogen, causing anthrax through a combination of bacterial infection and toxemia. B. anthracis causes natural infection in humans and animals and has been a top bioterrorism concern since the 2001 anthrax attacks in the USA. The exotoxins secreted by B. anthracis use CMG2 as the major toxin receptor and play essential roles in pathogenesis during the entire course of the disease. This review focuses on the activities of anthrax toxins and their roles in initial and late stages of anthrax infection.
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