Origin of the Functional Distinctiveness of NF-κB/p52.
Origin of the Functional Distinctiveness of NF-κB/p52.
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DOI：
10.3389/fcell.2021.764164
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发表时间：
2021
影响因子：
5.5
通讯作者：
Wang VY
中科院分区：
文献类型：
--
作者：
Ghosh G;Wang VY
NF-κB家族的转录调节因子已成为影响各种成体组织功能的关键因子。NF-κB家族转录因子是由五个单体（p50、p52、RelA、cRel和RelB）组成的同源和异源二聚体。该家族的特征在于其DNA结合和二聚化结构域的序列同源性，这使它们能够结合类似的DNA反应元件并通过转录激活和抑制数百个基因来参与类似的生物学程序。尽管家庭成员在序列和功能方面密切相关，但他们都表现出不同的活动。本文就NF-κB B/p52基因的序列特征、蛋白质与DNA的相互作用以及致病机制等方面进行综述。我们查明保守区域内的小序列变异，主要是负责其独特的功能特性。
The transcription regulators of the NF-κB family have emerged as a critical factor affecting the function of various adult tissues. The NF-κB family transcription factors are homo- and heterodimers made up of five monomers (p50, p52, RelA, cRel and RelB). The family is distinguished by sequence homology in their DNA binding and dimerization domains, which enables them to bind similar DNA response elements and participate in similar biological programs through transcriptional activation and repression of hundreds of genes. Even though the family members are closely related in terms of sequence and function, they all display distinct activities. In this review, we discuss the sequence characteristics, protein and DNA interactions, and pathogenic involvement of one member of family, NF-κB/p52, relative to that of other members. We pinpoint the small sequence variations within the conserved region that are mostly responsible for its distinct functional properties.
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影响因子：
64.5
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
10.1038/nsb0198-67
发表时间：
1998-01-01
期刊：
NATURE STRUCTURAL BIOLOGY
影响因子：
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通讯作者：
Ghosh, G
DOI：
10.4049/jimmunol.1501120
发表时间：
2016-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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