Targeted nanoparticles in mitochondrial medicine.
Targeted nanoparticles in mitochondrial medicine.
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DOI：
10.1002/wnan.1305
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发表时间：
2015-05
影响因子：
8.6
通讯作者：
Dhar, Shanta
中科院分区：
文献类型：
--
作者：
Pathak, Rakesh K.;Kolishetti, Nagesh;Dhar, Shanta
线粒体被称为“细胞的能量工厂”，不仅产生能量，而且在细胞死亡率管理方面也做出了巨大贡献。线粒体功能障碍导致多种疾病，包括但不限于癌症、动脉粥样硬化和神经退行性疾病。近年来，靶向线粒体成为控制线粒体功能障碍相关疾病的一种有吸引力的策略。尽管希望将治疗直接针对线粒体，但由于线粒体的高度复杂性，实际任务更加困难。将具有生物可降解性、磁化、荧光和近红外吸收等特性的纳米材料集成到纳米级尺寸的单个物体中的潜在好处可以导致开发针对线粒体的靶向治疗的混合纳米医学平台。最近，只有少数基于金属氧化物、金纳米颗粒、树枝、碳纳米管和脂质体的纳米颗粒被设计用于靶向线粒体。由于其有限的生物相容性，大多数这些材料在体内施用时面临巨大的挑战。可生物降解的聚合物纳米粒子成为有效药物输送的杰出候选者。在这篇综述中，我们重点介绍了可生物降解纳米颗粒平台作为线粒体医学有效靶向工具的当前开发进展。
Mitochondria, the so-called “energy factory of cells” not only produce energy but also contribute immensely in cellular mortality management. Mitochondrial dysfunctions result in various diseases including but not limited to cancer, atherosclerosis, and neurodegenerative diseases. In the recent years, targeting mitochondria emerged as an attractive strategy to control mitochondrial dysfunction related diseases. Despite the desire to direct therapeutics to the mitochondria, the actual task is more difficult due to the highly complex nature of the mitochondria. The potential benefits of integrating nanomaterials with properties such as biodegradability, magnetization, fluorescence, and near-infrared absorption into a single object of nanoscale dimensions can lead to the development of hybrid nano-medical platforms for targeting therapeutics to the mitochondria. Only a handful of nanoparticles based on metal oxides, gold nanoparticles, dendrons, carbon nanotubes, and liposomes were recently engineered to target mitochondria. Most of these materials face tremendous challenges when administered in vivo due to their limited biocompatibility. Biodegradable polymeric nanoparticles emerged as eminent candidates for effective drug delivery. In this review we highlight the current advancements in the development of biodegradable nanoparticle platforms as effective targeting tools for mitochondrial medicine.
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影响因子：
2.7
作者：
Einat, H;Yuan, P;Manji, HK
通讯作者：
Manji, HK
影响因子：
10.8
作者：
Boddapati, Sarathi V.;D'Souza, Gerard G. M.;Weissig, Volkmar
通讯作者：
Weissig, Volkmar
影响因子：
6.7
作者：
Battigelli, Alessia;Russier, Julie;Bianco, Alberto
通讯作者：
Bianco, Alberto
DOI：
10.1016/0921-8734(92)90021-g
发表时间：
1992-09-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
CORRALDEBRINSKI, M;SHOFFNER, JM;WALLACE, DC
通讯作者：
WALLACE, DC
影响因子：
4
作者：
Chamberlain, Graham R.;Tulumello, David V.;Kelley, Shana O.
通讯作者：
Kelley, Shana O.