Lipoprotein(a), a clinically elusive lipoprotein particle.
Lipoprotein(a), a clinically elusive lipoprotein particle.
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脂蛋白(a)，一种临床上难以捉摸的脂蛋白颗粒。
DOI：
10.1161/01.cir.95.2.295
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发表时间：
1997
期刊：
影响因子：
37.8
通讯作者：
S. Marcovina
中科院分区：
文献类型：
--
作者：
S. Fortmann;S. Marcovina
人血浆中存在脂蛋白（a）[Lp（a）]是Berg 1在1963年首次报道的与LDL相关的抗原。贝格和Mohr 2还在家族研究中发现，Lp（a）的存在是由常染色体遗传方式决定的。后来的研究提供的证据表明，Lp（a）是一种特殊的脂蛋白颗粒，其脂质组成与LDL非常相似。Lp（a）与LDL的不同之处在于存在一种高度糖基化的可变质量蛋白，称为载脂蛋白（a）[apo（a）]，通过共价键与载脂蛋白（apo）B-100连接。Lp（a）和冠心病之间的关联最早于20世纪70年代初报道，3但引发对Lp（a）的大量研究的是1987年发现的载脂蛋白（a）和纤溶酶原（凝血级联的关键蛋白）之间的结构同源性。4与纤溶酶原一样，载脂蛋白（a）由含Kringle结构域和丝氨酸蛋白酶结构域组成。载脂蛋白（a）Kringle结构域由纤溶酶原样Kringle 5结构域的一个拷贝和纤溶酶原样Kringle 4（K4）结构域的多个拷贝形成。10种基本的K4类型，5种命名为K4 1型至10型，存在于apo（a）中，所有都作为单个拷贝，除了K4 2型，其以从3至> 40的可变拷贝数存在。6 K4 2型重复的可变数目是apo（a）大小异质性的主要决定因素，除了apo（a）大小的异质性外，Lp（a）在血浆水平、赖氨酸结合特性以及脂质、碳水化合物和载脂蛋白组成方面也是异质性的，据报道，载脂蛋白E在血浆Lp（a）颗粒中占20%。
The existence of lipoprotein(a) [Lp(a)] in human plasma was first reported by Berg1 in 1963 as an antigen associated with LDL. Berg and Mohr2 also found in family studies that the presence of Lp(a) was genetically determined by an autosomal mode of inheritance. Later studies provided evidence that Lp(a) is a specific class of lipoprotein particles with a lipid composition very similar to that of LDL. Lp(a) differs from LDL by the presence of a highly glycosylated protein of variable mass, termed apolipoprotein(a) [apo(a)], linked by a covalent bond to apolipoprotein (apo) B-100. The association between Lp(a) and coronary heart disease was first reported in the early 1970s,3 but what triggered a vast train of research on Lp(a) was the discovery in 1987 of the structural homology between apo(a) and plasminogen, a key protein of the coagulation cascade.4 Like plasminogen, apo(a) is composed of a kringle-containing domain and a serine protease domain. Apo(a) kringle domain is formed by one copy of plasminogen-like kringle 5 domain and multiple copies of the plasminogen-like kringle 4 (K4) domain. Ten basic K4 types,5 designated K4 type 1 through 10, are present in apo(a), all as a single copy, except K4 type 2, which is present in a variable number of copies ranging from 3 to >40.6 The varying number of K4 type 2 repeats is the major determinant of apo(a) size heterogeneity,7 giving origin to the large number of apo(a) isoforms detected in human plasma.8 In addition to apo(a) size heterogeneity, Lp(a) is heterogeneous in plasma levels, lysine-binding properties, and lipid, carbohydrate, and apolipoprotein composition, with apo E reported in 20% of plasma Lp(a) particles.9 …
DOI：
10.1161/01.atv.13.8.1139
发表时间：
1993-08-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
BROWN, SA;HUTCHINSON, R;PATSCH, W
通讯作者：
PATSCH, W
脂蛋白（a）是年轻女性冠心病的决定因素。
影响因子：
37.8
作者：
Orth-Gomér,K;Mittleman,MA;Schenck-Gustafsson,K;Wamala,SP;Eriksson,M;Belkic,K;Kirkeeide,R;Svane,B;Rydén,L
通讯作者：
Rydén,L
一项针对斯坦福五城项目参与者的脂蛋白（a）水平和载脂蛋白（a）大小以及冠心病风险的前瞻性病例对照研究。
DOI：
10.1161/01.atv.17.2.239
发表时间：
1997
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Wild,SH;Fortmann,SP;Marcovina,SM
通讯作者：
Marcovina,SM