Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease.
Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease.
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DOI：
10.1101/gad.348897.121
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发表时间：
2021-11-01
影响因子：
10.5
通讯作者：
Berns A
中科院分区：
文献类型：
--
作者：
Alendar A;Berns A
在这篇综述中，Alfred和Berns讨论了新出现的证据，即染色体结构域解旋酶DNA结合（CHD）酶家族受到频繁的DNA拷贝数改变或突变，并显示在恶性肿瘤和其他人类疾病中的异常表达。染色质是高度动态的，在其结构和组蛋白类型以及由诸如转录、修复、复制和重组等过程控制的DNA修饰方面经历连续的全局变化。染色体结构域解旋酶DNA结合（CHD）家族的成员是ATP依赖性染色质重塑剂，其密切参与染色质动力学的调节、改变核小体结构和DNA可及性。在酵母、果蝇、斑马鱼和小鼠中的遗传研究强调了CHD酶在调节细胞命运和身份以及适当的胚胎发育中的重要作用。随着下一代测序技术的出现，有证据表明这些酶经常发生DNA拷贝数改变或突变，并在恶性肿瘤和其他人类疾病中表现出异常表达。因此，它们可能被证明是有价值的生物标志物或治疗干预的靶点。
In this review, Alendar and Berns discuss emerging evidence that the chromodomain helicase DNA-binding (CHD) family of enzymes is subjected to frequent DNA copy number alterations or mutations and shows aberrant expression in malignancies and other human diseases. Chromatin is highly dynamic, undergoing continuous global changes in its structure and type of histone and DNA modifications governed by processes such as transcription, repair, replication, and recombination. Members of the chromodomain helicase DNA-binding (CHD) family of enzymes are ATP-dependent chromatin remodelers that are intimately involved in the regulation of chromatin dynamics, altering nucleosomal structure and DNA accessibility. Genetic studies in yeast, fruit flies, zebrafish, and mice underscore essential roles of CHD enzymes in regulating cellular fate and identity, as well as proper embryonic development. With the advent of next-generation sequencing, evidence is emerging that these enzymes are subjected to frequent DNA copy number alterations or mutations and show aberrant expression in malignancies and other human diseases. As such, they might prove to be valuable biomarkers or targets for therapeutic intervention.
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16.6
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影响因子：
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通讯作者：
Sawyers CL