Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic.
Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic.
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DOI：
10.3389/fvets.2021.707368
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发表时间：
2021
影响因子：
3.2
通讯作者：
Yilmaz H
中科院分区：
文献类型：
--
作者：
Yilmaz A;Kayar A;Turan N;Iskefli O;Bayrakal A;Roman-Sosa G;Or E;Tali HE;Kocazeybek B;Karaali R;Bold D;Sadeyen JR;Lukosaityte D;Chang P;Iqbal M;Richt JA;Yilmaz H
最近的研究表明，家猫可以自然和实验感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。本研究旨在调查2019冠状病毒病（COVID-19）之前和COVID-19大流行期间，土耳其伊斯坦布尔家猫种群中SARS-CoV-2特异性抗体的存在情况。总的来说，在分析的155份猫血清中，26.45%（41/155）在刺突蛋白-ELISA（S-ELISA）中检测出阳性，28.38%（44/155）在受体结合结构域-ELISA（RBD-ELISA）中检测出阳性，21.9%（34/155）在S-和RBD-ELISA中检测出阳性。其中27人也对猫冠状病毒（FCoV）抗体的存在呈阳性。在34份SARS-CoV-2阳性血清中，其中3份血清中和试验呈阳性。COVID-19前的30只猫中有6只和COVID-19期间的125只猫中有28只被发现血清反应阳性。大约20%的ELISA阳性猫主要表现为呼吸道、胃肠道和肾脏体征和皮肤病变。红细胞压积，血红蛋白，白色血细胞，淋巴细胞，血小板数量低，约30%的ELISA阳性猫。在约20%的ELISA阳性猫中，中性粒细胞和单核细胞的数量高于正常值。23.5%的ELISA阳性猫的肝酶丙氨酸氨基转移酶水平高。总之，这是第一份描述土耳其伊斯坦布尔猫中SARS-CoV-2抗原（S和RBD）特异性抗体的报告，表明家猫从COVID-19的主人和/或家庭成员那里感染SARS-CoV-2的风险。这项研究和其他研究表明，COVID-19阳性的宠物主人应限制与伴侣动物的接触，并应监测有呼吸道症状的宠物是否感染SARS-CoV-2。
Recent studies demonstrated that domestic cats can be naturally and experimentally infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This study was performed to investigate the presence of SARS-CoV-2-specific antibodies within the domestic cat population in Istanbul, Turkey, before the coronavirus disease 2019 (COVID-19) and during the COVID-19 pandemic. Overall, from 155 cat sera analyzed, 26.45% (41/155) tested positive in the spike protein-ELISA (S-ELISA), 28.38% (44/155) in the receptor-binding domain-ELISA (RBD-ELISA), and 21.9% (34/155) in both, the S- and RBD-ELISAs. Twenty-seven of those were also positive for the presence of antibodies to feline coronavirus (FCoV). Among the 34 SARS-CoV-2-positive sera, three of those were positive on serum neutralization assay. Six of the 30 cats before COVID-19 and 28 of the 125 cats during COVID-19 were found to be seropositive. About 20% of ELISA-positive cats exhibited mainly respiratory, gastrointestinal, and renal signs and skin lesions. Hematocrit, hemoglobin, white blood cells, lymphocyte, and platelet numbers were low in about 30% of ELISA-positive cats. The number of neutrophils and monocytes were above normal values in about 20% of ELISA-positive cats. The liver enzyme alanine aminotransferase levels were high in 23.5% ELISA-positive cats. In conclusion, this is the first report describing antibodies specific to SARS-CoV-2 antigens (S and RBD) in cats in Istanbul, Turkey, indicating the risk for domestic cats to contract SARS-CoV-2 from owners and/or household members with COVID-19. This study and others show that COVID-19-positive pet owners should limit their contact with companion animals and that pets with respiratory signs should be monitored for SARS-CoV-2 infections.
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DOI：
10.3390/ani11061640
发表时间：
2021-06-01
期刊：
Animals : an open access journal from MDPI
影响因子：
--
作者：
Natale A;Mazzotta E;Mason N;Ceglie L;Mion M;Stefani A;Fincato A;Bonfante F;Bortolami A;Monne I;Bellinati L;Guadagno C;Quaranta E;Pastori A;Terregino C
通讯作者：
Terregino C
影响因子：
4.3
作者：
Sailleau, Corinne;Dumarest, Marine;Le Poder, Sophie
通讯作者：
Le Poder, Sophie
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
11.8
作者：
Barrs VR;Peiris M;Tam KWS;Law PYT;Brackman CJ;To EMW;Yu VYT;Chu DKW;Perera RAPM;Sit THC
通讯作者：
Sit THC
影响因子：
11.8
作者：
Garigliany M;Van Laere AS;Clercx C;Giet D;Escriou N;Huon C;van der Werf S;Eloit M;Desmecht D
通讯作者：
Desmecht D