SARS-Cov-2 Natural Infection in a Symptomatic Cat: Diagnostic, Clinical and Medical Management in a One Health Vision.
SARS-Cov-2 Natural Infection in a Symptomatic Cat: Diagnostic, Clinical and Medical Management in a One Health Vision.
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有症状猫的SARS-Cov-2自然感染：一个健康愿景中的诊断，临床和医疗管理。
DOI：
10.3390/ani11061640
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发表时间：
2021-06-01
期刊：
影响因子：
--
通讯作者：
Terregino C
中科院分区：
文献类型：
--
作者：
Natale A;Mazzotta E;Mason N;Ceglie L;Mion M;Stefani A;Fincato A;Bonfante F;Bortolami A;Monne I;Bellinati L;Guadagno C;Quaranta E;Pastori A;Terregino C
严重急性呼吸综合征冠状病毒2（SARS-Cov-2）是2019年冠状病毒病（COVID-19）的罪魁祸首。最近的参考文献中描述了实验感染的宠物（如狗、雪貂和猫）的易感性;此外，还报告了宠物（狗和猫）在自然条件下暴露于SARS-CoV-2感染的主人。据报道，大多数感染或暴露于SARS-CoV-2的猫都有轻度症状，而没有研究描述了症状猫的临床特征和诊断管理。这项工作报告了一只室内猫在与SARS-CoV-2感染的主人接触后出现疾病临床症状的案例，并重点关注实施多部门一体化健康方法的重要性。尽管宠物身上的病毒脱落似乎不足以感染家庭成员或其他动物，但应紧急考虑将通常的预防措施作为全球控制系统的一部分，因为这种涵盖人类和宠物的综合方法对于早期检测任何可能的病毒至关重要病毒突变。尽管有报道称SARS-CoV-2感染宠物的数量有所增加，但对自然感染的临床特征和有症状宠物的医疗随访的描述仍然没有充分的记录。这项研究报告了一只室内猫的病例，在其主人被诊断为COVID-19后，它表现出呼吸道症状和胃肠道综合征。胸部X线检查提示支气管肺炎，而血液检查提示轻度炎症过程。在他的主人检测出病毒阳性14天后，通过针对SARS-CoV-2基因的RT-qPCR检测，鼻和口咽拭子检测出阳性。鼻拭子在31天后持续为RT-qPCR阳性。血清学通过ELISA、电化学发光分析和空斑减少中和试验证实了抗体的存在，在31天后记录到高抗体滴度。猫在接受药物治疗后好转，临床痊愈。这项研究表明，暴露于SARS-CoV-2可能导致猫沿着上呼吸道SARS-CoV-2 RNA的自然感染和支气管肺炎，尽管水平较低。猫产生了中和抗体，31天后达到高滴度。进一步描述SARS-CoV-2自然感染的宠物，它们的医疗管理和诊断结果将有助于提高对易感动物COVID-19的认识。
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is responsible for Coronavirus Disease 2019 (COVID-19). The susceptibility of experimentally infected pets, such as dogs, ferrets and cats, has been described in the recent bibliography; furthermore, the exposure of pets (dogs and cats) to SARS-CoV-2-infected owners under natural conditions was also reported. Most of the cats infected or exposed to SARS-CoV-2 were reported to be mildly symptomatic, while no study has described the clinical features and diagnostic management of symptomatic cats. This work reports the case of an indoor cat that developed clinical signs of disease after being in contact with SARS-CoV-2-infected owners and focuses on the importance of implementing a multisectoral One Health approach. Even though the viral shedding from pets does not appear sufficient to infect family members or other animals, the usual precautionary measures should urgently be considered as part of a global control system, as this integrated approach encompassing both humans and pets is pivotal for the early detection of any possible viral mutation. Despite the reported increase in SARS-CoV-2-infected pets, the description of the clinical features from natural infection and the medical follow up in symptomatic pets is still not sufficiently documented. This study reports the case of an indoor cat that displayed respiratory signs and a gastrointestinal syndrome, following the COVID-19 diagnosis of his owners. Thoracic radiographies were suggestive of bronchial pneumonia, while blood tests were indicative of a mild inflammatory process. Nasal and oropharyngeal swabs tested positive through RT-qPCR assays targeting SARS-CoV-2 genes 14 days after his owners tested positive for the virus. Nasal swabs persisted to be RT-qPCR positive after 31 days. Serology confirmed the presence of antibodies through ELISA, electrochemiluminescence analysis and plaque reduction neutralization test, recording a high antibody titre after 31 days. The cat improved after medical treatment and clinically recovered. This study suggests that exposure to SARS-CoV-2 could lead to a natural infection with bronchial pneumonia in cats along with a possible prolonged persistence of SARS-CoV-2 RNA in the upper airways, albeit at a low level. The cat developed neutralizing antibodies, reaching a high titre after 31 days. Further descriptions of SARS-CoV-2 naturally infected pets, their medical management and diagnostic findings would be useful to enhance knowledge about COVID-19 in susceptible animals.
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影响因子：
1.7
作者：
Bouillon, Juliette;Duke, Tanya;Cosford, Kevin L.
通讯作者：
Cosford, Kevin L.
影响因子：
11.8
作者：
Barrs VR;Peiris M;Tam KWS;Law PYT;Brackman CJ;To EMW;Yu VYT;Chu DKW;Perera RAPM;Sit THC
通讯作者：
Sit THC
影响因子：
11.8
作者：
Garigliany M;Van Laere AS;Clercx C;Giet D;Escriou N;Huon C;van der Werf S;Eloit M;Desmecht D
通讯作者：
Desmecht D
DOI：
10.1073/pnas.2013102117
发表时间：
2020-10-20
影响因子：
11.1
作者：
Bosco-Lauth, Angela M.;Hartwig, Airn E.;Bowen, Richard A.
通讯作者：
Bowen, Richard A.
影响因子：
64.8
作者：
Ge XY;Li JL;Yang XL;Chmura AA;Zhu G;Epstein JH;Mazet JK;Hu B;Zhang W;Peng C;Zhang YJ;Luo CM;Tan B;Wang N;Zhu Y;Crameri G;Zhang SY;Wang LF;Daszak P;Shi ZL
通讯作者：
Shi ZL