Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000-2017.
Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000-2017.
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DOI：
10.1038/s41370-020-0212-8
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发表时间：
2020-07
影响因子：
4.5
通讯作者：
Nielsen C
中科院分区：
文献类型：
--
作者：
Norén E;Lindh C;Rylander L;Glynn A;Axelsson J;Littorin M;Faniband M;Larsson E;Nielsen C
农业杀虫剂广泛用于杂草和害虫控制，导致这些化合物在食物中残留。一般人群主要通过饮食摄入接触。接触某些农药与不利的人类健康结果有关。我们的目的是评估尿液中常用农药的生物标志物的浓度和时间趋势。样本收集自2000年至2017年瑞典斯堪尼亚的青少年（n = 1060）。使用LC-MS/MS分析了尿液中14种农药生物标志物的浓度。使用线性回归评估了生物标志物浓度（ln转换）的时间趋势。在所有采样年份，在>90%的种群中检测到拟除虫菊酯（3-PBA和DCCA）、毒死蜱（TCPy）、矮壮素（CCC）、噻菌灵（OH-TBZ）和代森锰锌（ETU）的生物标志物。生物标志物CCC和TCPy的中位浓度最高（>0.8 µg/L），而生物标志物氟氯氰菊酯（4F-3-PBA）和两种拟除虫菊酯（CFCA）的中位浓度最低（<0.02 µg/L）。发现生物标志物3-PBA（3.7%/年）、TCPy（1.7%/年）以及生物标志物嘧霉胺（11.9%/年）和戊唑醇（12.2%/年）的时间趋势增加。CCC（-5.5%/年）、OH-TBZ（-5.5%/年）和ETU（-3.9%/年）呈下降趋势。我们的研究结果表明，瑞典青少年通常暴露于低浓度的农药（中位浓度<3.88微克/升）。
Agricultural pesticides are extensively used for weed- and pest control, resulting in residues of these compounds in food. The general population is mainly exposed through dietary intake. Exposure to certain pesticides has been associated with adverse human health outcomes. Our aim was to assess urinary concentrations and temporal trends in the biomarkers of commonly used pesticides. Samples were collected from adolescents (n = 1060) in Scania, Sweden, from 2000 to 2017. Concentrations of 14 pesticide biomarkers were analyzed in urine using LC–MS/MS. Temporal trends in biomarker concentrations (ln-transformed) were evaluated using linear regression. Biomarkers of pyrethroids (3-PBA and DCCA), chlorpyrifos (TCPy), chlormequat (CCC), thiabendazole (OH-TBZ), and mancozeb (ETU) were detected in >90% of the population all sampling years. The biomarkers CCC and TCPy had the highest median concentrations (>0.8 µg/L), whereas the biomarkers of cyfluthrin (4F-3-PBA) and two pyrethroids (CFCA) had the lowest median concentrations (<0.02 µg/L). Increasing temporal trends were found for the biomarkers 3-PBA (3.7%/year), TCPy (1.7%/year) and biomarkers of pyrimethanil (11.9%/year) and tebuconazole (12.2%/year). Decreasing trends were found for CCC (–5.5%/year), OH-TBZ (−5.5%/year), and ETU (−3.9%/year). Our results suggest that Swedish adolescents are commonly exposed to pesticides in low concentrations (median concentrations <3.88 µg/L).
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影响因子：
3.8
作者：
Axelstad, Marta;Boberg, Julie;Hass, Ulla
通讯作者：
Hass, Ulla
DOI：
10.1038/jes.2014.14
发表时间：
2014-11-01
影响因子：
4.5
作者：
Fustinoni, Silvia;Mercadante, Rosa;Moretto, Angelo
通讯作者：
Moretto, Angelo
影响因子：
10.4
作者：
Barr DB;Olsson AO;Wong LY;Udunka S;Baker SE;Whitehead RD;Magsumbol MS;Williams BL;Needham LL
通讯作者：
Needham LL
影响因子：
4.5
作者：
Galea KS;MacCalman L;Jones K;Cocker J;Teedon P;Cherrie JW;van Tongeren M
通讯作者：
van Tongeren M
DOI：
10.1016/j.jchromb.2014.10.003
发表时间：
2014-12-15
影响因子：
3
作者：
Ekman, Eva;Faniband, Moosa H.;Lindh, Christian H.
通讯作者：
Lindh, Christian H.