Iron status and self-reported fatigue in blood donors.
Iron status and self-reported fatigue in blood donors.
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DOI：
10.1111/trf.16095
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发表时间：
2021-01
期刊：
影响因子：
2.9
通讯作者：
Mast AE
中科院分区：
文献类型：
--
作者：
Spencer BR;Fox MP;Wise LA;Cable RG;Mast AE
据报道，疲劳是缺铁的一种症状，但对献血者的研究没有显示出决定性的联系。我们对STRIDE随机试验的数据进行了观察性分析，以评估铁状态与自我报告的疲劳之间的关系。三个血液中心随机分配692名经常献血者接受教育或补铁治疗。在20至24个月的随访期间测量铁状态的生物标志物。疲劳评分来自基线和最后一次访问时的11项问卷，并评估铁状态和疲劳之间的关系。对337名受试者的最终实验室和问卷数据进行了评估。基线时，女性、年龄较大和贫血与疲劳有关，但铁含量与疲劳无关。平均（±SD）疲劳评分变化为0.0（±0.5）。铁储量的平均（±SD）增加为1.0（±3.5）mg/kg，但体内铁储量的变化与疲劳评分的变化无关（0.01 / mg/kg; 95% CI, - 0.01至0.02）或疲劳（RR, 1.01; 95% CI， 0.99至1.04）。与疲劳评分变化相关的唯一因素是基线疲劳（0.36;95% CI， 0.25至0.48）。在高频供血者中，基线铁状态和铁状态的变化都不能预测随访期间的疲劳，改善仅限于基线疲劳水平较高的患者。对铁与献血者疲劳之间关系的评估得益于对研究设计和研究人群的仔细考虑。
Fatigue is a reported symptom of iron depletion, but studies in blood donors show no conclusive link. We conducted an observational analysis of data from the STRIDE randomized trial to evaluate association of iron status with self-reported fatigue. Three blood centers randomly assigned 692 frequent donors to education or iron supplementation treatments. Biomarkers for iron status were measured during 20 to 24 months of follow-up. A fatigue score was derived from an 11-item questionnaire at baseline and final visits, and associations between iron status and fatigue were assessed. Final lab and questionnaire data were evaluable from 337 subjects. At baseline, female sex, older age, and anemia were associated with fatigue, but iron status was not. Mean (±SD) fatigue score change was 0.0 (±0.5). Mean (±SD) increase in iron stores was 1.0 (±3.5) mg/kg, but changes in body iron stores were not associated with fatigue score changes (0.01 per mg/kg; 95% CI, −0.01 to 0.02) or with fatigue (RR, 1.01; 95% CI, 0.99 to 1.04). The only factor associated with fatigue score changes was baseline fatigue (0.36; 95% CI, 0.25 to 0.48). Among high-frequency donors, neither iron status at baseline nor changes in iron status predicted fatigue during follow-up, with improvements limited to those with higher levels of baseline fatigue. Assessment of the association between iron and fatigue in blood donors benefits from careful consideration of study design and the study population.
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DOI：
10.1016/s0140-6736(17)31928-1
发表时间：
2017-11-25
期刊：
Lancet (London, England)
影响因子：
--
作者：
Di Angelantonio E;Thompson SG;Kaptoge S;Moore C;Walker M;Armitage J;Ouwehand WH;Roberts DJ;Danesh J;INTERVAL Trial Group
通讯作者：
INTERVAL Trial Group
影响因子：
39.2
作者：
BEUTLER, E;LARSH, SE;GURNEY, CW
通讯作者：
GURNEY, CW
影响因子：
4.2
作者：
Haas, JD;Brownlie, T
通讯作者：
Brownlie, T
影响因子：
20.3
作者：
Krayenbuehl, Pierre-Alexandre;Battegay, Edouard;Schulthess, Georg
通讯作者：
Schulthess, Georg
影响因子：
4.7
作者：
Junghaenel, Doerte U.;Christodoulou, Christopher;Stone, Arthur A.
通讯作者：
Stone, Arthur A.