Parahydrogen-Induced Polarization of Diethyl Ether Anesthetic.
Parahydrogen-Induced Polarization of Diethyl Ether Anesthetic.
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DOI：
10.1002/chem.202002528
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发表时间：
2020-10-27
期刊：
影响因子：
--
通讯作者：
Chekmenev EY
中科院分区：
文献类型：
--
作者：
Ariyasingha NM;Joalland B;Younes HR;Salnikov OG;Chukanov NV;Kovtunov KV;Kovtunova LM;Bukhtiyarov VI;Koptyug IV;Gelovani JG;Chekmenev EY
人们对评估局部肺功能的磁共振成像 (MRI) 越来越感兴趣，这依赖于使用核自旋超极化气体作为造影剂。尽管存在成本高、生产通量低以及临床 MRI 扫描仪上 129Xe 成像面临的挑战（通常仅配备质子检测）等限制，但超极化 129Xe 的长气相寿命使得这种吸入式造影剂可以被当今的临床研究所接受。我们报告了质子超极化乙醚的低成本和高通量制备，它可以使用所有临床 MRI 扫描仪上常用的质子检测，以无毒、简单且灵敏的总体策略用于肺部成像。乙醚通过成对仲氢加成到乙烯基乙醚上而超极化，并通过 1 H NMR 光谱进行表征。在几秒钟内接近完全化学转化时，质子极化水平超过 8%，从而在整个检测过程中通过受激发射辐射 (RASER) 激活无线电放大。尽管超极化二乙醚（分压为 0.5 bar）的气相 T1 弛豫非常有效，T1 约为 1。 1.2 其次，我们证明，在低磁场下，使用通过成对仲氢添加产生的长寿命单线态可将弛豫衰减延长约 3 倍，为生物成像及其他应用铺平道路。二乙醚麻醉剂通过乙烯基乙基醚上成对的仲氢加成而被 NMR 超极化。在数秒内几乎完成化学转化时，质子极化水平超过 8%。尽管气相 T1 约为 1.2 秒，但使用低磁场中产生的长寿命单线态可将弛豫衰减延长约 3 倍，为生物成像及其他应用铺平道路。
The growing interest in magnetic resonance imaging (MRI) for assessing regional lung function relies on the use of nuclear-spin hyperpolarized gas as a contrast agent. The long gas-phase lifetimes of hyperpolarized 129Xe make this inhalable contrast agent acceptable for clinical research today despite limitations such as high cost, low throughput of production and challenges of 129Xe imaging on clinical MRI scanners, which are normally equipped with proton detection only. We report on low-cost and high-throughput preparation of proton-hyperpolarized diethyl ether, which can be potentially employed for pulmonary imaging with a non-toxic, simple, and sensitive overall strategy using proton detection commonly available on all clinical MRI scanners. Diethyl ether is hyperpolarized by pairwise parahydrogen addition to vinyl ethyl ether and characterized by 1H NMR spectroscopy. Proton polarization levels exceeding 8% are achieved at near complete chemical conversion within seconds, causing the activation of radio amplification by stimulated emission radiation (RASER) throughout detection. Although gas-phase T1 relaxation of hyperpolarized diethyl ether (at partial pressure of 0.5 bar) is very efficient with T1 of ca. 1.2 second, we demonstrate that at low magnetic fields, the use of long-lived singlet states created via pairwise parahydrogen addition extends the relaxation decay by approximately 3-fold, paving the way to bioimaging applications and beyond. Diethyl ether anesthetic is NMR hyperpolarized by pairwise parahydrogen addition to vinyl ethyl ether. Proton polarization levels exceeding 8% are achieved at near complete chemical conversion within seconds. Although gas-phase T1 is ~1.2 s, the use of long-lived singlet states created in low magnetic field extends the relaxation decay by approximately 3-fold, paving the way to bioimaging applications and beyond.
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影响因子：
4.6
作者：
Cavallari E;Carrera C;Sorge M;Bonne G;Muchir A;Aime S;Reineri F
通讯作者：
Reineri F
影响因子：
8.6
作者：
Carravetta, M;Johannessen, OG;Levitt, MH
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Levitt, MH
影响因子：
2.2
作者：
Graafen, Dirk;Belen Franzoni, Maria;Muennemann, Kerstin
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Muennemann, Kerstin
影响因子：
3.3
作者：
Choquet, P;Hyacinthe, JN;Ziegler, A
通讯作者：
Ziegler, A
影响因子：
3.7
作者：
Ariyasingha, Nuwandi M.;Salnikov, Oleg G.;Chekmenev, Eduard Y.
通讯作者：
Chekmenev, Eduard Y.