Herpesviruses: latency and reactivation - viral strategies and host response.

Herpesviruses: latency and reactivation - viral strategies and host response.
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DOI:
10.3402/jom.v5i0.22766
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发表时间:
2013-10-25
影响因子:
4.5
通讯作者:
Grinde B
Grinde B
中科院分区:
医学2区
文献类型:
--
作者:
Grinde B

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疱疹病毒科的八名成员通常感染人类,近100%的成年人口至少感染其中一种。引起最大健康问题的五种病毒是:单纯疱疹病毒(HSV)1型和2型、EB病毒(EBV)、巨细胞病毒(CMV)和水痘带状疱疹病毒(VZV)。此外,还有人类疱疹病毒(HHV)6-8型。综述首先介绍了可能的病毒策略。各种人类疱疹病毒的特殊生物学和宿主关系,包括它们的病理学,随后被检查。讨论了有助于维持病毒复制潜伏期和重新激活的因素。将特别提到这些病毒如何利用口腔中的病理并对其做出贡献。重新激活并不一定意味着临床症状,正如EBV和CMV从口腔粘膜无症状地脱落所反映的那样。免疫反应和病毒输出水平对所经历的后果都很重要。
Eight members of the Herpesviridae family commonly infect humans, and close to 100% of the adult population is infected with at least one of these. The five that cause the most health concerns are: herpes simplex virus (HSV) type 1 and 2, Epstein–Barr virus (EBV), cytomegalovirus (CMV), and varicella zoster virus (VZV). In addition, there are human herpes virus (HHV) types 6–8. The review starts by introducing possible viral strategies in general. The particular biology and host relationship of the various human herpesviruses, including their pathology, are examined subsequently. Factors that contribute to the maintenance of latency and reactivation of viral replication are discussed. There will be special reference to how these viruses exploit and contribute to pathology in the oral cavity. Reactivation does not necessarily imply clinical symptoms, as reflected in the asymptomatic shedding of EBV and CMV from oral mucosa. The immune response and the level of viral output are both important to the consequences experienced.
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