Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia.
Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia.
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龈下微生物区系和与慢性特发性中性粒细胞减少症相关的青春期前牙周炎的治疗。
DOI：
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发表时间：
1998
影响因子：
6.7
通讯作者：
M. Nakou
中科院分区：
文献类型：
--
作者：
J. Kamma;Nick A. Lygidakis;M. Nakou
青春期前牙周炎影响乳牙和恒牙。本研究的目的是检查一名 11 岁白人女性恒牙龈下微生物群的组成，该女性在 5 岁时乳牙过早脱落，以及这种情况对抗生素治疗和支持性牙周护理的反应。牙龈组织高度发炎，放射线检查发现牙槽骨丢失。女孩经常出现上呼吸道感染、扁桃体炎和反复发作的中耳炎。她的母亲有与慢性特发性中性粒细胞减少症相关的早发性牙周炎病史。还进行了血液化学测试和免疫学检查。从恒磨牙、门牙、犬齿和上颌前磨牙的近端部位采集龈下菌斑样本。从龈下微生物区系中分离出 27 种不同的微生物物种。主要菌种包括牙龈卟啉单胞菌（17.6%-7.3%）、中间普氏菌（12.4%-4.7%）、痰二氧化碳嗜二氧化碳菌（14.4%-10.4%）、赭二氧化碳嗜二氧化碳菌（13.2%-6.9%）和伴放线放线杆菌(9.3%-5.5%)。牙周治疗包括洗牙、根面平整以及抗生素给予奥格门汀 312.5 毫克和灭滴灵 200 毫克，每次 t.i.d. 10天。抗生素治疗3周后，从相同部位采集细菌样本。所有牙周病原体均恢复到较低水平，并且 A.actinomycetemcomitans 在 3 周内几乎被消除。 3、6和12个月的临床指标评估表明，牙周联合抗生素治疗是有效的，并且很快临床改善显着。抗生素治疗后3、6和12个月以及每次牙周支持治疗前的微生物监测显示，治疗后12个月牙周病原菌仍处于较低水平波动，并且通过每3个月的牙周支持治疗可维持在较低水平。
Prepubertal periodontitis affects both primary and permanent dentition. The purpose of this study was to examine the composition of subgingival microflora of the permanent dentition in an 11-year-old Caucasian female, who had premature exfoliation of her deciduous teeth on her 5th year of age, and the response of this condition to the antibiotic therapy and supportive periodontal care. Gingival tissues were highly inflamed and alveolar bone loss was detected radiographically. The girl had experienced frequent upper respiratory tract infections, tonsilitis and recurrent otitis media. Her mother had history of early onset periodontitis associated with chronic idiopathic neutropenia. Blood chemistry tests and immunological examinations were also performed. Subgingival plaque samples were collected from the proximal sites of permanent molars, incisors, canines and maxillary premolars. 27 different microbial species were isolated from the subgingival microflora. Among the predominant species were Porphyromonas gingivalis (17.6%-7.3%), Prevotella intermedia (12.4%-4.7%), Capnocytophaga sputigena (14.4%-10.4%), Capnocytophaga ochracea (13.2%-6.9%) and Actinobacillus actinomycetemcomitans (9.3%-5.5%). Periodontal treatment consisted of scaling, root planing in conjunction with antibiotic administration of Augmentin 312.5 mg and Flagyl 200 mg, each t.i.d. for 10 days. 3 weeks after the antibiotic therapy, bacterial samples were collected from the same sites. All the periodontal pathogens were recovered in lower levels and A.actinomycetemcomitans was almost eliminated in the 3-week period. The evaluation of clinical indices at 3, 6 and 12 months showed that periodontal treatment in conjunction with antibiotics was effective and rapidly followed by marked clinical improvement. The microbiological monitoring at 3, 6 and 12 months after antibiotic treatment and each time prior to supportive periodontal care, revealed that the periodontal pathogens fluctuated in low levels even 12 months after treatment and could be maintained at low level by supportive periodontal care at 3-month intervals.
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牙周病发病机制中的免疫功能障碍。
影响因子：
6.7
作者：
Shenker,BJ
通讯作者：
Shenker,BJ
福赛拟杆菌在成人牙龈炎和牙周炎中的作用。
影响因子：
--
作者：
Lai,CH;Listgarten,MA;Shirakawa,M;Slots,J
通讯作者：
Slots,J
影响因子：
4.3
作者：
Page,RC;Bowen,T;Altman,L;Vandesteen,E;Ochs,H;Mackenzie,P;Osterberg,S;Engel,LD;Williams,BL
通讯作者：
Williams,BL
影响因子：
--
作者：
RAMS, TE;FEIK, D;SLOTS, J
通讯作者：
SLOTS, J
局限性青春期前牙周炎的患病率和微生物学。
影响因子：
--
作者：
Sweeney,EA;Alcoforado,GA;Nyman,S;Slots,J
通讯作者：
Slots,J