Comparative efficacy evaluation of different CSF vaccines in pigs with CSF maternally derived antibodies.
Comparative efficacy evaluation of different CSF vaccines in pigs with CSF maternally derived antibodies.
复制标题
不同脑脊液疫苗对具有脑脊液母源抗体的猪的功效比较评估。
DOI：
10.1016/j.vetmic.2022.109541
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发表时间：
2022-08
影响因子：
3.3
通讯作者：
Guanghua Chen
中科院分区：
文献类型：
--
作者：
Ning Chen;Qin Wang;Yulong Hu;Yanyong Sun;Junping Li;Huawei Wu;Lu Xu;Huanhuan Liu;Chenghuai Yang;Xiaochun Chen;Yong Deng;Yingju Xia;Qianyi Zhang;Shi Cheng;Aihua Fan;Guanghua Chen
猪瘟是中国发生的一种传染性很强的重要猪瘟。尽管大量接种了脑脊液C株疫苗，但仍有报告称有轻微临床症状的零星暴发。疫苗失败的一个可能原因可能是在现场接种疫苗期间母源抗体(MDA)的干扰。这项研究的目的是评估不同的脑脊液疫苗在有MDA存在的情况下的效力，并评估现场不同的疫苗接种方案。结果表明，单剂接种C株PK疫苗可保护猪抵抗严重的临床症状，并显著减少病毒血症。多边开发协定的影响可以忽略不计。在使用C-菌株-ST疫苗的基础和加强疫苗接种计划期间，干扰也很轻微。相比之下，在一次性接种计划中，MDA对亚单位E2疫苗的效力有显著影响，尽管诱导了强劲的E2抗体，但猪在攻击后表现出严重的临床症状、脑脊液相关死亡、典型的病理损害和高水平的病毒血症。一项现场疫苗接种和挑战研究进一步证实，与现场应用的常规基础和加强免疫方案相比，在有MDA的情况下，单剂C-株PK疫苗的效果更好，猪出现发热、慢性体征、明显的病毒血症和攻击后脱落。将疫苗接种时间从28日龄推迟到45d，此时丙二醛含量较低，有利于提高疫苗的临床保护力和免疫力。综上所述，本研究结果强调，高质量的疫苗和以血清学监测为基础的科学的疫苗接种方案是控制和消除中国脑脊液的重要支柱。
Classical swine fever (CSF) is a highly contagious and important swine disease in China. Sporadic outbreaks with mild clinical signs are still being reported despite massive vaccination with the CSF C-strain vaccine. One possible reason for vaccine failure could be interference from maternally derived antibodies (MDAs) during vaccination in the field. The aim of this study was to evaluate the efficacy of different CSF vaccines in the presence of MDAs and to assess the different vaccination schemes in the field. The results demonstrated that vaccination with a single dose of C-strain-PK vaccine protected pigs against severe clinical signs and significantly reduced viremia. The impact of MDAs was negligible. The interference was also mild during a prime and boost vaccination scheme using the C-strain-ST vaccine. In contrast, a significant influence of MDAs on the efficacy of the subunit E2 vaccine in a one-dose vaccination scheme was observed, with pigs showing severe clinical signs, CSF-associated death, typical pathological lesions and a high level of viremia after challenge, despite robust E2 antibody induction. A field vaccination and challenge study further confirmed the superior effectiveness of a single dose of C-strain-PK vaccine in the presence of MDAs in comparison to a routine prime and boost vaccination scheme applied in the field, with pigs having fever, chronic signs, significant viremia and shedding after challenge. Delaying the vaccination time from the age of 28 days to 45 days, when MDA was low, was beneficial for improving the clinical protection and immunity induced by vaccines. Altogether, the results presented here emphasize that a high-quality vaccine and a scientific design of the vaccination scheme based on serological surveillance are essential pillars to control and eliminate CSF in China.
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影响因子：
3.7
作者：
Graham SP;Everett HE;Haines FJ;Johns HL;Sosan OA;Salguero FJ;Clifford DJ;Steinbach F;Drew TW;Crooke HR
通讯作者：
Crooke HR
影响因子：
4.4
作者：
Postel A;Schmeiser S;Bernau J;Meindl-Boehmer A;Pridotkas G;Dirbakova Z;Mojzis M;Becher P
通讯作者：
Becher P
影响因子：
2.6
作者：
Coronado, Liani;Alejandro Bohorquez, Jose;Ganges, Llilianne
通讯作者：
Ganges, Llilianne
影响因子：
3.3
作者：
Wang, Qin;Liu, Huanhuan;Chen, Guanghua
通讯作者：
Chen, Guanghua
影响因子：
--
作者：
V. Singh;K. Rajak;Ravi Kumar;S. Raut;A. Saxena;D. Muthuchelvan;R. Singh;A. B. Pandey
通讯作者：
V. Singh;K. Rajak;Ravi Kumar;S. Raut;A. Saxena;D. Muthuchelvan;R. Singh;A. B. Pandey