Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart.
Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart.
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DOI：
10.1016/j.ydbio.2016.03.014
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发表时间：
2016-05-15
影响因子：
2.7
通讯作者：
Pu, William T.
中科院分区：
文献类型：
--
作者：
Stevens, Sean M.;von Gise, Alexander;VanDusen, Nathan;Zhou, Bin;Pu, William T.
存在于成体组织中的巨噬细胞的一个亚群来源于胎儿卵黄囊，而其他亚群来源于循环单核细胞。这些本体不同的巨噬细胞亚群在组织损伤反应中具有不同的作用，胚胎群体总体上在心脏修复中具有有益的活性。在这里，我们表明，胎儿卵黄巨噬细胞招募到一个壁龛内，心外膜，心脏的间皮覆盖。心外膜是建立卵黄囊巨噬细胞所必需的，心外膜的这一功能依赖于转录因子WT 1的表达。因此，组织特异性的线索和转录程序招募或保留胚胎巨噬细胞在他们的最终住所，在那里他们帮助塑造器官稳态和损伤反应。
A subset of macrophages that reside in adult tissues originate from the fetal yolk sac, while others derive from circulating monocytes. These ontologically different macrophage subsets have distinct roles in tissue injury responses, with the embryonic population overall having beneficial activity in cardiac repair. Here we show that fetal yolk macrophages are recruited to a niche within and just below the epicardium, the mesothelial covering of the heart. The epicardium was required for establishment of yolk sac macrophages in this region of the fetal heart, and this function of epicardium depended on its expression of the transcription factor WT1. Thus, tissue-specific cues and transcriptional programs recruit or retain embryonic macrophages in their final abodes, where they help to shape organ homeostasis and injury responses.
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影响因子：
64.8
作者：
Gomez Perdiguero E;Klapproth K;Schulz C;Busch K;Azzoni E;Crozet L;Garner H;Trouillet C;de Bruijn MF;Geissmann F;Rodewald HR
通讯作者：
Rodewald HR
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H
影响因子：
2.7
作者：
von Gise A;Zhou B;Honor LB;Ma Q;Petryk A;Pu WT
通讯作者：
Pu WT
影响因子：
64.8
作者：
Zhou, Bin;Ma, Qing;Pu, William T.
通讯作者：
Pu, William T.
影响因子：
64.8
作者：
Qian, Bin-Zhi;Li, Jiufeng;Zhang, Hui;Kitamura, Takanori;Zhang, Jinghang;Campion, Liam R.;Kaiser, Elizabeth A.;Snyder, Linda A.;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.