The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular Disease and Cancer.
The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular Disease and Cancer.
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DOI：
10.3390/nu14173499
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发表时间：
2022-08-25
期刊：
影响因子：
5.9
通讯作者：
Sarrafzadegan, Nizal
中科院分区：
文献类型：
--
作者：
Mohammadifard, Noushin;Haghighatdoost, Fahimeh;Rahimlou, Mehran;Santos Rodrigues, Ana Paula;Gaskarei, Mohammadamin Khajavi;Okhovat, Paria;de Oliveira, Cesar;Silveira, Erika Aparecida;Sarrafzadegan, Nizal
心血管疾病和癌症分别是全球第一和第二大死亡原因。流行病学证据表明，心血管疾病患者的癌症发病率升高，反之亦然。然而，尽管这两种疾病之间存在共同的危险因素，如代谢异常和生活方式，但这些疾病通常被视为独立的事件。队列研究表明，控制心血管疾病危险因素可能对癌症发病率有影响。因此，可以得出结论，改善心血管疾病和癌症共同危险因素的干预措施可能有效预防和治疗这两种疾病。生酮饮食（KD）是一种低碳水化合物和高脂肪饮食，已被广泛用于代谢异常的减肥计划。此外，最近的研究已经研究了KD对包括心血管疾病和癌症在内的许多疾病的治疗作用，因为它在促进酮解、生酮和改变许多其他代谢途径方面具有潜在的有益健康作用。然而，对于心血管疾病或癌症患者开KD处方仍存在很大争议。考虑到关于该主题的研究数量众多，显然有必要总结KD改善心血管健康和控制细胞增殖的潜在机制。在这篇综述中，我们解释了KD的历史，它的类型和生理作用，并讨论了它在心血管疾病和癌症治疗和预防中的作用。
Cardiovascular disease (CVD) and cancer are the first and second leading causes of death worldwide, respectively. Epidemiological evidence has demonstrated that the incidence of cancer is elevated in patients with CVD and vice versa. However, these conditions are usually regarded as separate events despite the presence of shared risk factors between both conditions, such as metabolic abnormalities and lifestyle. Cohort studies suggested that controlling for CVD risk factors may have an impact on cancer incidence. Therefore, it could be concluded that interventions that improve CVD and cancer shared risk factors may potentially be effective in preventing and treating both diseases. The ketogenic diet (KD), a low-carbohydrate and high-fat diet, has been widely prescribed in weight loss programs for metabolic abnormalities. Furthermore, recent research has investigated the effects of KD on the treatment of numerous diseases, including CVD and cancer, due to its role in promoting ketolysis, ketogenesis, and modifying many other metabolic pathways with potential favorable health effects. However, there is still great debate regarding prescribing KD in patients either with CVD or cancer. Considering the number of studies on this topic, there is a clear need to summarize potential mechanisms through which KD can improve cardiovascular health and control cell proliferation. In this review, we explained the history of KD, its types, and physiological effects and discussed how it could play a role in CVD and cancer treatment and prevention.
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