Current Understanding of the Pathogenesis of Dengue Virus Infection.
Current Understanding of the Pathogenesis of Dengue Virus Infection.
复制标题
DOI：
10.1007/s00284-020-02284-w
复制
发表时间：
2021-01
影响因子：
2.6
通讯作者：
Arunkumar G
中科院分区：
文献类型：
--
作者：
Bhatt P;Sabeena SP;Varma M;Arunkumar G
登革病毒感染的发病机制是病毒、宿主基因和宿主免疫应答之间复杂的相互作用。宿主因素如抗体依赖性增强（ADE）、记忆交叉反应性T细胞、抗DENV NS1抗体、自身免疫以及遗传因素是疾病易感性的主要决定因素。NS1蛋白和抗DENV NS1抗体被认为是重症登革的发病机制。交叉反应性CD4+ T细胞的细胞因子应答可能被不同DENV血清型的连续感染改变，导致促炎细胞因子的进一步升高，从而导致有害的免疫应答。Fcγ受体介导的抗体依赖性增强（ADE）导致免疫细胞释放细胞因子，导致血管内皮细胞功能障碍和血管通透性增加。登革病毒的基因组变异和抑制宿主免疫应答的亚基因组黄病毒RNA（sfRNA）是疾病严重程度的病毒决定因素。登革病毒感染可导致产生针对DENV NS 1抗原、DENV prM和E蛋白的自身抗体，这些抗体可与多种自身抗原如纤溶酶原、整合素和血小板细胞交叉反应。除病毒因素外，一些宿主遗传因素和基因多态性也在DENV感染的发病机制中发挥作用。这篇综述文章强调了登革热发病机制的各种因素，并强调了与生物标志物相关的领域的最新进展，这些生物标志物可用于未来预测严重疾病的结果。
The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein and anti-DENV NS1 antibodies were believed to be responsible for pathogenesis of severe dengue. The cytokine response of cross-reactive CD4+ T cells might be altered by the sequential infection with different DENV serotypes, leading to further elevation of pro-inflammatory cytokines contributing a detrimental immune response. Fcγ receptor-mediated antibody-dependent enhancement (ADE) results in release of cytokines from immune cells leading to vascular endothelial cell dysfunction and increased vascular permeability. Genomic variation of dengue virus and subgenomic flavivirus RNA (sfRNA) suppressing host immune response are viral determinants of disease severity. Dengue infection can lead to the generation of autoantibodies against DENV NS1antigen, DENV prM, and E proteins, which can cross-react with several self-antigens such as plasminogen, integrin, and platelet cells. Apart from viral factors, several host genetic factors and gene polymorphisms also have a role to play in pathogenesis of DENV infection. This review article highlights the various factors responsible for the pathogenesis of dengue and also highlights the recent advances in the field related to biomarkers which can be used in future for predicting severe disease outcome.
登录
查看更多内容
DOI：
10.4269/ajtmh.2008.79.495
发表时间：
2008-10-01
影响因子：
3.3
作者：
Chen, Hui-Ling;Lin, Su-Ru;Wang, Wei-Kung
通讯作者：
Wang, Wei-Kung
影响因子：
5.4
作者：
Cologna, R;Armstrong, PM;Rico-Hesse, R
通讯作者：
Rico-Hesse, R
DOI：
10.4269/ajtmh.1988.38.172
发表时间：
1988-01-01
影响因子：
3.3
作者：
BURKE, DS;NISALAK, A;SCOTT, RM
通讯作者：
SCOTT, RM
Sanofi-Pasteur登革热疫苗的好处和风险：建模最佳部署。
DOI：
10.1126/science.aaf9590
发表时间：
2016-09-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ferguson NM;Rodríguez-Barraquer I;Dorigatti I;Mier-Y-Teran-Romero L;Laydon DJ;Cummings DA
通讯作者：
Cummings DA
影响因子：
3.8
作者：
Chen HR;Chuang YC;Lin YS;Liu HS;Liu CC;Perng GC;Yeh TM
通讯作者：
Yeh TM